Anti-beta Dystroglycan antibody (ab103905)

Overview

  • Product nameAnti-beta Dystroglycan antibody
    See all beta Dystroglycan primary antibodies
  • Description
    Goat polyclonal to beta Dystroglycan
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Rat, Human
    Predicted to work with: Rabbit, Cow, Dog
  • Immunogen

    Synthetic peptide:

    C-HVGKHEYFMHATDK

    , corresponding to internal sequence amino acids 569-582 of Human beta Dystroglycan (NP_004384.3).

  • Positive control
    • Human Skeletal Muscle lysates.
  • General notesReported variants represent identical protein: NP_001159400.1, NP_004384.3.

Properties

Applications

Our Abpromise guarantee covers the use of ab103905 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Predicted molecular weight: 97 kDa.

Target

  • RelevanceDystroglycans are essential elements of the neuromuscular junction (NMJ). The gene for dystroglycan is expressed as a precursor protein that is post translationally cleaved into a 156 kDa extracellular peripheral membrane protein called alpha dystroglycan and a 43 kDa transmembrane protein, beta dystroglycan. The latter protein contains a PPxY motif that promotes binding to WW domain containing proteins, such as utrophin and dystrophin. Phosphorylation at tyrosine 892 within the PPxY motif may regulate c Src interactions with beta dystroglycan, as well as inhibit interactions with WW domain proteins. In skeletal muscle, beta dystroglycan is normally localized to the plasma membrane, however phosphorylation of Tyr892 leads to localization of beta dystroglycan to endosomal compartments along with c Src. Thus, phosphorylation at Tyr892 may have important roles in altering the localization of beta dystroglycan during NMJ formation.
  • Cellular localizationType I membrane protein.
  • Database links
  • Alternative names
    • 156DAG antibody
    • A3a antibody
    • AGRNR antibody
    • Beta DG antibody
    • Beta dystroglycan antibody
    • DAG 1 antibody
    • DAG1 antibody
    • Dystroglycan antibody
    • Dystrophin associated glycoprotein 1 antibody
    see all

Anti-beta Dystroglycan antibody images

  • Anti-beta Dystroglycan antibody (ab103905) at 0.2 µg/ml + Human Skeletal Muscle lysate at 35 µg

    Predicted band size : 97 kDa
  • All lanes : Anti-beta Dystroglycan antibody (ab103905) at 0.1 µg/ml

    Lane 1 : Mouse Skeletal Muscule Lysate in RIPA buffer
    Lane 2 : Rat Skeletal Muscule Lysate in RIPA buffer

    Lysates/proteins at 35 µg per lane.

    Developed using the ECL technique

    Predicted band size : 97 kDa

References for Anti-beta Dystroglycan antibody (ab103905)

ab103905 has not yet been referenced specifically in any publications.

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