Anti-beta glucuronidase (GUSB) antibody (ab103112)


  • Product nameAnti-beta glucuronidase (GUSB) antibody
    See all beta glucuronidase (GUSB) primary antibodies
  • Description
    Rabbit polyclonal to beta glucuronidase (GUSB)
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within internal sequence amino acids 341-371 of Human beta glucuronidase (GUSB).

  • Positive control
    • WiDr, A2058, K562 cell line lysates and Human colon carcinoma tissue.



Our Abpromise guarantee covers the use of ab103112 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 75 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.


  • FunctionPlays an important role in the degradation of dermatan and keratan sulfates.
  • Involvement in diseaseDefects in GUSB are the cause of mucopolysaccharidosis type 7 (MPS7) [MIM:253220]; also known as Sly syndrome. MPS7 is an autosomal recessive lysosomal storage disease characterized by inability to degrade glucuronic acid-containing glycosaminoglycans. The phenotype is highly variable, ranging from severe lethal hydrops fetalis to mild forms with survival into adulthood. Most patients with the intermediate phenotype show hepatomegaly, skeletal anomalies, coarse facies, and variable degrees of mental impairment.
    Note=Mucopolysaccharidosis type 7 is associated with non-immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non-immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders.
  • Sequence similaritiesBelongs to the glycosyl hydrolase 2 family.
  • Post-translational
    N-linked glycosylated with 3 to 4 oligosaccharide chains.
  • Cellular localizationLysosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • Ac2-223 antibody
    • asd antibody
    • Beta G1 antibody
    • Beta glucuronidase antibody
    • Beta-G1 antibody
    • Beta-glucuronidase antibody
    • BG antibody
    • BGLR antibody
    • BGLR_HUMAN antibody
    • FLJ39445 antibody
    • Glucuronidase beta antibody
    • Gur antibody
    • Gus antibody
    • Gus-r antibody
    • Gus-s antibody
    • Gus-t antibody
    • Gus-u antibody
    • GUSB antibody
    • Gut antibody
    • MPS7 antibody
    see all

Anti-beta glucuronidase (GUSB) antibody images

  • All lanes : Anti-beta glucuronidase (GUSB) antibody (ab103112) at 1/100 dilution

    Lane 1 : WiDr cell lysate
    Lane 2 : A2058 cell lysate
    Lane 3 : K562 cell lysate

    Lysates/proteins at 35 µg per lane.

    Predicted band size : 75 kDa
  • ab103112 at 1/50 dilution staining beta glucuronidase (GUSB) in Human colon carcinoma by Immunohistochemistry Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining

References for Anti-beta glucuronidase (GUSB) antibody (ab103112)

ab103112 has not yet been referenced specifically in any publications.

Product Wall

We have not tested anti-beta-glucuronidase ab103112 for reactivity with mouse samples. Based on alignment of the antibody immunogen amino acid sequence with the sequence of mouse beta glucuronidase, reactivity is unlikely.