Anti-beta glucuronidase (GUSB) antibody [EPR10616] (ab166904)


  • Product name
    Anti-beta glucuronidase (GUSB) antibody [EPR10616]
    See all beta glucuronidase (GUSB) primary antibodies
  • Description
    Rabbit monoclonal [EPR10616] to beta glucuronidase (GUSB)
  • Host species
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IF, Flow Cytmore details
    Unsuitable for: IP
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide corresponding to residues in Human beta glucuronidase (GUSB) (UniProt ID: P08236).

  • Positive control
    • Human fetal liver lysate, K562, HepG2 and 293T cell lysates, paraffin-embedded Human liver and skin tissue, HepG2 cells, K562 cells.
  • General notes

    This product is a recombinant rabbit monoclonal antibody.

    Mouse, Rat: We have preliminary internal testing data to indicate this antibody may not react with these species. Please contact us for more information.

    Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents



Our Abpromise guarantee covers the use of ab166904 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/1000 - 1/5000. Predicted molecular weight: 78 kDa.
IHC-P 1/50 - 1/100. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF 1/100 - 1/250.
Flow Cyt 1/100 - 1/500.

ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.


  • Application notes
    Is unsuitable for IP.
  • Target

    • Function
      Plays an important role in the degradation of dermatan and keratan sulfates.
    • Involvement in disease
      Defects in GUSB are the cause of mucopolysaccharidosis type 7 (MPS7) [MIM:253220]; also known as Sly syndrome. MPS7 is an autosomal recessive lysosomal storage disease characterized by inability to degrade glucuronic acid-containing glycosaminoglycans. The phenotype is highly variable, ranging from severe lethal hydrops fetalis to mild forms with survival into adulthood. Most patients with the intermediate phenotype show hepatomegaly, skeletal anomalies, coarse facies, and variable degrees of mental impairment.
      Note=Mucopolysaccharidosis type 7 is associated with non-immune hydrops fetalis, a generalized edema of the fetus with fluid accumulation in the body cavities due to non-immune causes. Non-immune hydrops fetalis is not a diagnosis in itself but a symptom, a feature of many genetic disorders, and the end-stage of a wide variety of disorders.
    • Sequence similarities
      Belongs to the glycosyl hydrolase 2 family.
    • Post-translational
      N-linked glycosylated with 3 to 4 oligosaccharide chains.
    • Cellular localization
    • Information by UniProt
    • Database links
    • Alternative names
      • Ac2-223 antibody
      • asd antibody
      • Beta G1 antibody
      • Beta glucuronidase antibody
      • Beta-G1 antibody
      • Beta-glucuronidase antibody
      • BG antibody
      • BGLR antibody
      • BGLR_HUMAN antibody
      • FLJ39445 antibody
      • Glucuronidase beta antibody
      • Gur antibody
      • Gus antibody
      • Gus-r antibody
      • Gus-s antibody
      • Gus-t antibody
      • Gus-u antibody
      • GUSB antibody
      • Gut antibody
      • MPS7 antibody
      see all


    • All lanes : Anti-beta glucuronidase (GUSB) antibody [EPR10616] (ab166904) at 1/1000 dilution

      Lane 1 : Human fetal liver lysate
      Lane 2 : K562 cell lysate
      Lane 3 : HepG2 cell lysate
      Lane 4 : 293T cell lysate

      Lysates/proteins at 10 µg per lane.

      All lanes : goat anti-rabbit HRP IgG antibody at 1/2000 dilution

      Predicted band size: 78 kDa

    • Immunohistochemical analysis of paraffin-embedded Human liver tissue labeling beta glucuronidase (GUSB) with ab166904 at 1/50 dilution.
    • Immunohistochemical analysis of paraffin-embedded Human skin tissue labeling beta glucuronidase (GUSB) with ab166904 at 1/50 dilution.
    • Immunofluorescent analysis of HepG2 cells labeling beta glucuronidase (GUSB) with ab166904 at 1/100 dilution.
    • Flow cytometric analysis of permeabilized K562 cells labeling beta glucuronidase (GUSB) with ab166904 at 1/100 dilution (red) or a rabbit IgG negative (green).


    ab166904 has not yet been referenced specifically in any publications.

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