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Products:Microbiology >> Toxin >> Bacterial Toxin >> Cholera Toxin
Overview
Product name
Anti-beta subunit Cholera Toxin antibody
See all beta subunit Cholera Toxin products (9) ...
Description
Mouse monoclonal to beta subunit Cholera Toxin
Specificity
This antibody reacts with the beta subunit of cholera toxin and does not cross-react with the alpha subunit.
Tested applications
ELISAmore details
Immunogen
Purified beta subunit of cholera toxin.
Properties
Form
Liquid
Storage instructions
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
Storage buffer
PBS, pH 7.2, sodium azide, 0.1%
Concentration
Concentration information loading...
Purity
Protein A purified
Clonality
Monoclonal
Isotype
IgG1
Research areas
Microbiology >> Toxin >> Bacterial Toxin >> Cholera Toxin
Applications
Show applications key
Our Abpromise guarantee covers the use of ab1003 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
ELISA
Application notes
Dilute in PBS or medium which is identical to that used in the assay system.
Average indirect ELISA titer is1:1,000,000.
Is unsuitable for WB.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
Target
Relevance
The B subunit of cholera toxin (CtxB) binds to a GM1-ganglioside receptor, a ubiquitous glycolipid cell surface receptor. This binding is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin A subunit into cells. The beta chain has no toxic activity by itself. The holotoxin consists of a pentameric ring of B subunits whose central pore is occupied by the A subunit. The A subunit contains two chains, A1 and A2, linked by a disulfide bridge. The A subunit (and Cholera toxin) activates the adenylate cyclase enzyme in cells of the intestinal mucosa leading to increased levels of intracellular cAMP.
Cellular localization
Secreted
Alternative names
- Cholera enterotoxin B chain antibody
- Cholera enterotoxin beta chain antibody
- Cholera enterotoxin gamma chain antibody
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References for Anti-beta subunit Cholera Toxin antibody (ab1003)
ab1003 has not yet been referenced specifically in any publications.
Publishing research using ab1003? Please let us know so that we can cite the reference in this datasheet
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"