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Product Name
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beta subunit Cholera Toxin antibody
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See all beta subunit Cholera Toxin antibodies (12)...
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Product type
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Primary antibodies
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Description
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Mouse monoclonal to beta subunit Cholera Toxin
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Immunogen
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Purified beta subunit of cholera toxin.
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Specificity
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This antibody reacts with the beta subunit of cholera toxin and does not cross-react with the alpha subunit.
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Tested applications
(see key)
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ELISA
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Abreviews
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Application notes
(see key)
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Recommended dilutions
Dilute in PBS or medium which is identical to that used in the assay system.
Average indirect ELISA titer is1:1,000,000.
Is unsuitable for WB.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Cellular localization
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Secreted
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Research areas
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Microbiology >> Toxin >> Bacterial Toxin >> Cholera Toxin
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Relevance
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The B subunit of cholera toxin (CtxB) binds to a GM1-ganglioside receptor, a ubiquitous glycolipid cell surface receptor. This binding is widely accepted to initiate toxin action by triggering uptake and delivery of the toxin A subunit into cells. The beta chain has no toxic activity by itself. The holotoxin consists of a pentameric ring of B subunits whose central pore is occupied by the A subunit. The A subunit contains two chains, A1 and A2, linked by a disulfide bridge.
The A subunit (and Cholera toxin) activates the adenylate cyclase enzyme in cells of the intestinal mucosa leading to increased levels of intracellular cAMP.
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Raised in
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Mouse
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Clonality
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Monoclonal
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Isotype
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IgG1
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Purity
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Protein A purified
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Storage buffer
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PBS, pH 7.2, sodium azide, 0.1% Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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1.000 mg/ml
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Storage instructions
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Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this beta subunit Cholera Toxin antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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Search PubMed (MEDLINE) for references to beta subunit Cholera Toxin
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