Overview

  • Product name
    Anti-beta Synuclein antibody
    See all beta Synuclein primary antibodies
  • Description
    Chicken polyclonal to beta Synuclein
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Fusion protein, corresponding to amino acids 1-134 of Human beta Synuclein.

  • Positive control
    • E.Coli derived fusion protein.

Properties

Applications

Our Abpromise guarantee covers the use of ab16420 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/2000. Predicted molecular weight: 15 kDa.

Target

  • Function
    Non-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
  • Tissue specificity
    Expressed predominantly in brain; concentrated in presynaptic nerve terminals.
  • Sequence similarities
    Belongs to the synuclein family.
  • Post-translational
    modifications
    Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
  • Cellular localization
    Cytoplasm.
  • Information by UniProt
  • Database links
  • Alternative names
    • 14 kDa brain-specific protein antibody
    • Beta-synuclein antibody
    • Phosphoneuroprotein 14 antibody
    • PNP14 antibody
    • Sncb antibody
    • Synuclein beta antibody
    • SYUB_HUMAN antibody
    see all

Images



  • Predicted band size : 15 kDa


    Ab16420 at a 1/2000 dilution staining beta Synuclein by Western blot. Colorimetric method was used for signal development. The arrow points to beta Synuclein fusion protein.

References

ab16420 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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