Anti-beta Synuclein antibody (ab6164)

Overview

  • Product nameAnti-beta Synuclein antibody
    See all beta Synuclein primary antibodies
  • Description
    Sheep polyclonal to beta Synuclein
  • SpecificityCross reactivity: This antibody is known to react with rat and human and other rodents. Cross reactivity with other species has not been tested yet.
  • Tested applicationsSuitable for: IHC-P, IHC-Frmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide IEPLMEPEGESYEDPPQE corresponds to the carboxy terminal sequence of human beta-synuclein (108-125) and coupled to diphtheria toxoid via a cysteine residue attached to the C- terminal. The conjugate was cross-linked by maleimidocaproyl-N-hydroxy succinimide.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab6164 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
IHC-Fr
  • Application notesImmunohistochemistry: 1 ug/ml
    Western Blot: Not tested.
    Immunoblot: Not tested.
    1 site ELISA: Not tested.
    Biological Inhibition: Not tested.
  • Target

    • FunctionNon-amyloid component of senile plaques found in Alzheimer disease. Could act as a regulator of SNCA aggregation process. Protects neurons from staurosporine and 6-hydroxy dopamine (6OHDA)-stimulated caspase activation in a p53/TP53-dependent manner. Contributes to restore the SNCA anti-apoptotic function abolished by 6OHDA. Not found in the Lewy bodies associated with Parkinson disease.
    • Tissue specificityExpressed predominantly in brain; concentrated in presynaptic nerve terminals.
    • Sequence similaritiesBelongs to the synuclein family.
    • Post-translational
      modifications
      Phosphorylated. Phosphorylation by G-protein coupled receptor kinases (GRK) is more efficient than phosphorylation by CK1, CK2 and CaM-kinase II.
    • Cellular localizationCytoplasm.
    • Information by UniProt
    • Database links
    • Alternative names
      • 14 kDa brain-specific protein antibody
      • Beta-synuclein antibody
      • Phosphoneuroprotein 14 antibody
      • PNP14 antibody
      • Sncb antibody
      • Synuclein beta antibody
      • SYUB_HUMAN antibody
      see all

    References for Anti-beta Synuclein antibody (ab6164)

    ab6164 has not yet been referenced specifically in any publications.

    Product Wall

    Ab6164 is stored in 5mM Tris-HCl, 0.9% NaCl. Please contact us again if you have any additional questions.

    All of the information we have for each of the anti-human-synuclein antibodies in our catalog is on the online datasheets. We are not aware of studies where they might have been used to detect relative levels of synuclein expression in leukocytes.

    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"