Overview

  • Product name
    Anti-BFSP2 antibody
  • Description
    Rabbit polyclonal to BFSP2
  • Tested applications
    Suitable for: IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    antigen sequence: LSRNYEEDVK LLHKQLAGCE LEQMDAPIGT GLDDILETIR IQWERDVEKN RVEAGALLQA KQQAEVAHMS QTQEEKLAAA LRVE, corresponding to internal sequence amino acids 237-320 of Human BFSP2.

  • Positive control
    • Human lateral ventricle tissue; A 431 cells.

Properties

Applications

Our Abpromise guarantee covers the use of ab122476 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/2500 - 1/5000. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
ICC/IF Use a concentration of 1 - 4 µg/ml. using PFA/Triton X-100 Fixation/Permeabilization.

Target

  • Function
    Involved in stabilization of lens fiber cell cytoskeleton.
  • Tissue specificity
    Lens.
  • Involvement in disease
    Defects in BFSP2 are the cause of cataract autosomal dominant BFSP2-related (ADC-BFSP2) [MIM:611597]; also known as cataract autosomal dominant multiple types 1. Cataract is an opacification of the crystalline lens of the eye that frequently results in visual impairment or blindness. Opacities vary in morphology, are often confined to a portion of the lens, and may be static or progressive. In general, the more posteriorly located and dense an opacity, the greater the impact on visual function. Cataract autosomal dominant BFSP2-related is characterized by a variable phenotype that may or may not be consistent within a family. The opacities can be nuclear, sutural, stellate cortical, lamellar, cortical, nuclear embryonic, Y-sutural, punctate cortical, congenital or with juvenile- and adult-onset.
  • Sequence similarities
    Belongs to the intermediate filament family.
  • Cellular localization
    Membrane. Cytoplasm. Cytoplasm > cytoskeleton. Membrane- and cytoskeleton-associated.
  • Information by UniProt
  • Database links
  • Alternative names
    • 49 kDa cytoskeletal protein antibody
    • Beaded filament protein CP49 antibody
    • Beaded filament structural protein 2 antibody
    • Beaded filament structural protein 2, phakinin antibody
    • Bfps2, Cytoskeletal protein, 49 kD antibody
    • BFSP2 antibody
    • BFSP2_HUMAN antibody
    • CP47 antibody
    • CP49 antibody
    • Lens fiber cell beaded filament protein CP 47 antibody
    • Lens fiber cell beaded filament protein CP 49 antibody
    • Lens intermediate filament-like light antibody
    • LIFL-L antibody
    • MGC142078 antibody
    • MGC142080 antibody
    • Phakinin antibody
    • PHAKOSIN antibody
    see all

Images

  • ab122476 staining BFSP2 in paraffin-embedded Human lateral ventricle tissue by Immunohistochemistry.
  • ab122476 at 4 µg/ml staining BFSP2 in PFA/Triton X-100 fixed/permeabilized A431 cells by Immunofluorescence (green).

References

ab122476 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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