Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab57354 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionComponent of the BHC complex, a corepressor complex that represses transcription of neuron-specific genes in non-neuronal cells. The BHC complex is recruited at RE1/NRSE sites by REST and acts by deacetylating and demethylating specific sites on histones, thereby acting as a chromatin modifier. In the BHC complex, it may act as a scaffold. Inhibits KDM1A-mediated demethylation of 'Lys-4' of histone H3 in vitro, suggesting a role in demethylation regulation.
    • Tissue specificityHighly expressed in brain. Expressed at much lower level in other tissues.
    • Sequence similaritiesContains 1 A.T hook DNA-binding domain.
      Contains 1 PHD-type zinc finger.
    • Cellular localizationNucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • BHC80a antibody
      • BM-006 antibody
      • BRAF35-HDAC complex protein BHC80 antibody
      • BRAF35/HDAC2 complex (80 kDa) antibody
      • KIAA1696 antibody
      • PF21A_HUMAN antibody
      • PHD finger protein 21A antibody
      • PHF21A antibody
      see all

    Anti-BHC80 / PHF21A antibody images

    • Western blot against tagged recombinant protein immunogen using ab57354 BHC80 / PHF21A antibody at 1ug/ml. Predicted band size of immunogen is 37 kDa

    References for Anti-BHC80 / PHF21A antibody (ab57354)

    ab57354 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"