Anti-Bile Acid Receptor NR1H4 antibody (ab28480)

Overview

• Product name
  Anti-Bile Acid Receptor NR1H4 antibody
  See all Bile Acid Receptor NR1H4 primary antibodies
• Description
  Rabbit polyclonal to Bile Acid Receptor NR1H4
• Tested applications
  Suitable for: WBmore details
• Species reactivity
  Reacts with: Mouse
  Predicted to work with: Rat, Human
• Immunogen

  Synthetic peptide:

  R(224)KNVKQHADQTVNED(238)

  , corresponding to amino acids 224/238 of Mouse FXR (Peptide available as ab39820.)

  Run BLAST with Run BLAST with
• Positive control
  • Mouse liver samples

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
• Storage buffer
  Preservative: 0.05% Sodium Azide
  Constituents: PBS, 1mg/ml BSA
• Concentration information loading...
• Purity
  Immunogen affinity purified
• Clonality
  Polyclonal
• Isotype
  IgG
• Research areas
  • Signal Transduction
  • Metabolism
  • Energy Metabolism

  • Epigenetics and Nuclear Signaling
  • Nuclear Signaling Pathways
  • Nuclear Receptors
  • Orphan Nuclear Receptors

  • Signal Transduction
  • Metabolism
  • Lipid metabolism

  • Metabolism
  • Pathways and Processes
  • Metabolic signaling pathways
  • Energy transfer pathways
  • Energy Metabolism

  • Metabolism
  • Types of disease
  • Cancer

Associated products

• Compatible Secondaries
  • Goat Anti-Rabbit IgG H&L (Alexa Fluor® 488) (ab150077)
  • Goat Anti-Rabbit IgG H&L (HRP) (ab205718)
• Immunizing Peptide (Blocking)
  • Mouse Bile Acid Receptor NR1H4 peptide (ab39820)

Applications

Target

• Function
  Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
• Sequence similarities
  Belongs to the nuclear hormone receptor family. NR1 subfamily.
  Contains 1 nuclear receptor DNA-binding domain.
• Cellular localization
  Nucleus.

• Target information above from: UniProt accession Q96RI1 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 9971 Human
  • Entrez Gene: 20186 Mouse
  • Entrez Gene: 60351 Rat
  • Omim: 603826 Human
  • SwissProt: Q96RI1 Human
  • SwissProt: Q60641 Mouse
  • SwissProt: Q62735 Rat
  • Unigene: 282735 Human

  • Unigene: 3095 Mouse
  • Unigene: 42943 Rat

  see all
• Alternative names
  • BAR antibody
  • Bile acid receptor antibody
  • Farnesoid X activated receptor antibody

  • Farnesoid X receptor antibody
  • Farnesoid X-activated receptor antibody
  • Farnesol receptor HRR 1 antibody
  • Farnesol receptor HRR-1 antibody
  • Farnesol receptor HRR1 antibody
  • FXR antibody
  • HRR 1 antibody
  • HRR1 antibody
  • NR1H4 antibody
  • NR1H4_HUMAN antibody
  • Nuclear receptor subfamily 1 group H member 4 antibody
  • Retinoid X receptor interacting protein 14 antibody
  • Retinoid X receptor-interacting protein 14 antibody
  • RIP 14 antibody
  • RIP14 antibody
  • RXR interacting protein 14 antibody
  • RXR-interacting protein 14 antibody

  see all

Protocols

• Western blot protocols