Anti-Bile Acid Receptor NR1H4 antibody (ab28480)

Overview

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab28480 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500. Detects a band of approximately 55 kDa (predicted molecular weight: 55 kDa).Can be blocked with Mouse Bile Acid Receptor NR1H4 peptide (ab39820).

Target

  • FunctionLigand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
  • Sequence similaritiesBelongs to the nuclear hormone receptor family. NR1 subfamily.
    Contains 1 nuclear receptor DNA-binding domain.
  • Cellular localizationNucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • BAR antibody
    • Bile acid receptor antibody
    • Farnesoid X activated receptor antibody
    • Farnesoid X receptor antibody
    • Farnesoid X-activated receptor antibody
    • Farnesol receptor HRR 1 antibody
    • Farnesol receptor HRR-1 antibody
    • Farnesol receptor HRR1 antibody
    • FXR antibody
    • HRR 1 antibody
    • HRR1 antibody
    • NR1H4 antibody
    • NR1H4_HUMAN antibody
    • Nuclear receptor subfamily 1 group H member 4 antibody
    • Retinoid X receptor interacting protein 14 antibody
    • Retinoid X receptor-interacting protein 14 antibody
    • RIP 14 antibody
    • RIP14 antibody
    • RXR interacting protein 14 antibody
    • RXR-interacting protein 14 antibody
    see all

References for Anti-Bile Acid Receptor NR1H4 antibody (ab28480)

ab28480 has not yet been referenced specifically in any publications.

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