Anti-Bile Acid Receptor NR1H4 antibody (ab86025)

Overview

  • Product name
    Anti-Bile Acid Receptor NR1H4 antibody
    See all Bile Acid Receptor NR1H4 primary antibodies
  • Description
    Rabbit polyclonal to Bile Acid Receptor NR1H4
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Three synthetic peptides (human) conjugated to KLH

  • Positive control
    • An induced culture of E. coli

Properties

Applications

Our Abpromise guarantee covers the use of ab86025 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notes
    WB: 1/1000. Detects a band of approximately 70 kDa (predicted molecular weight: 56 kDa). Tag is 14kDa.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Ligand-activated transcription factor. Receptor for bile acids such as chenodeoxycholic acid, lithocholic acid and deoxycholic acid. Represses the transcription of the cholesterol 7-alpha-hydroxylase gene (CYP7A1) through the induction of NR0B2 or FGF19 expression, via two distinct mechanisms. Activates the intestinal bile acid-binding protein (IBABP). Activates the transcription of bile salt export pump ABCB11 by directly recruiting histone methyltransferase CARM1 to this locus.
    • Sequence similarities
      Belongs to the nuclear hormone receptor family. NR1 subfamily.
      Contains 1 nuclear receptor DNA-binding domain.
    • Cellular localization
      Nucleus.
    • Information by UniProt
    • Database links
    • Alternative names
      • BAR antibody
      • Bile acid receptor antibody
      • Farnesoid X activated receptor antibody
      • Farnesoid X receptor antibody
      • Farnesoid X-activated receptor antibody
      • Farnesol receptor HRR 1 antibody
      • Farnesol receptor HRR-1 antibody
      • Farnesol receptor HRR1 antibody
      • FXR antibody
      • HRR 1 antibody
      • HRR1 antibody
      • NR1H4 antibody
      • NR1H4_HUMAN antibody
      • Nuclear receptor subfamily 1 group H member 4 antibody
      • Retinoid X receptor interacting protein 14 antibody
      • Retinoid X receptor-interacting protein 14 antibody
      • RIP 14 antibody
      • RIP14 antibody
      • RXR interacting protein 14 antibody
      • RXR-interacting protein 14 antibody
      see all

    Images

    • All lanes : Anti-Bile Acid Receptor NR1H4 antibody (ab86025) at 1/1000 dilution

      Lane 1 : An un-induced culture of E. coli
      Lane 2 : An induced culture of E. coli

      Lysates/proteins at 1/5000 dilution per lane.

      Secondary
      Anti-Rabbit IgG HRP at 1/1000 dilution

      Predicted band size : 56 kDa
      Observed band size : 45,70 kDa (why is the actual band size different from the predicted?)


      Exposure time : 60 minutes

    References

    ab86025 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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