Validated using a knockout cell line

Anti-Bim antibody [Y36] (ab32158)

Publishing research using ab32158? Please let us know so that we can cite the reference in this datasheet.

ab32158 has been referenced in 31 publications.

  • Liu B  et al. RACKI induces chemotherapy resistance in esophageal carcinoma by upregulating the PI3K/AKT pathway and Bcl-2 expression. Onco Targets Ther 11:211-220 (2018). PubMed: 29379302
  • Ma L  et al. Long non-coding RNA XIST promotes cell growth and invasion through regulating miR-497/MACC1 axis in gastric cancer. Oncotarget 8:4125-4135 (2017). WB ; Human . PubMed: 27911852
  • Déry MA & LeBlanc AC Luman contributes to brefeldin A-induced prion protein gene expression by interacting with the ERSE26 element. Sci Rep 7:42285 (2017). WB ; Human . PubMed: 28205568
  • Zhang XQ  et al. High glucose induces apoptosis via upregulation of Bim expression in proximal tubule epithelial cells. Oncotarget 8:24119-24129 (2017). WB, ICC/IF ; Human . PubMed: 28445931
  • Yang N  et al. Propofol inhibits lung cancer cell viability and induces cell apoptosis by upregulating microRNA-486 expression. Braz J Med Biol Res 50:e5794 (2017). WB . PubMed: 28076456
  • Zhang ZF  et al. MicroRNA-182 downregulates Wnt/ß-catenin signaling, inhibits proliferation, and promotes apoptosis in human osteosarcoma cells by targeting HOXA9. Oncotarget 8:101345-101361 (2017). PubMed: 29254169
  • Girnius N & Davis RJ JNK Promotes Epithelial Cell Anoikis by Transcriptional and Post-translational Regulation of BH3-Only Proteins. Cell Rep 21:1910-1921 (2017). PubMed: 29141222
  • Wang C  et al. Bifidobacterial recombinant thymidine kinase-ganciclovir gene therapy system induces FasL and TNFR2 mediated antitumor apoptosis in solid tumors. BMC Cancer 16:545 (2016). WB ; Human . PubMed: 27464624
  • Sheng YH  et al. MUC13 protects colorectal cancer cells from death by activating the NF-?B pathway and is a potential therapeutic target. Oncogene N/A:N/A (2016). PubMed: 27399336
  • Chi HC  et al. Chemotherapy resistance and metastasis-promoting effects of thyroid hormone in hepatocarcinoma cells are mediated by suppression of FoxO1 and Bim pathway. Cell Death Dis 7:e2324 (2016). WB . PubMed: 27490929
  • Liu MH  et al. Resveratrol inhibits doxorubicin-induced cardiotoxicity via sirtuin 1 activation in H9c2 cardiomyocytes. Exp Ther Med 12:1113-1118 (2016). WB ; Rat . PubMed: 27446329
  • Leverson JD  et al. Potent and selective small-molecule MCL-1 inhibitors demonstrate on-target cancer cell killing activity as single agents and in combination with ABT-263 (navitoclax). Cell Death Dis 6:e1590 (2015). Human . PubMed: 25590800
  • Fallahi-Sichani M  et al. Systematic analysis of BRAF(V600E) melanomas reveals a role for JNK/c-Jun pathway in adaptive resistance to drug-induced apoptosis. Mol Syst Biol 11:797 (2015). PubMed: 25814555
  • Xiao Y  et al. MCL-1 Is a Key Determinant of Breast Cancer Cell Survival: Validation of MCL-1 Dependency Utilizing a Highly Selective Small Molecule Inhibitor. Mol Cancer Ther 14:1837-47 (2015). WB ; Human . PubMed: 26013319
  • Li J  et al. Effect of HM910, a novel camptothecin derivative, on the inhibition of multiple myeloma cell growth in vitro and in vivo. Am J Cancer Res 5:1000-16 (2015). Human . PubMed: 26045982
  • Hearn JM  et al. Potent organo-osmium compound shifts metabolism in epithelial ovarian cancer cells. Proc Natl Acad Sci U S A 112:E3800-5 (2015). Human . PubMed: 26162681
  • Andrews MC  et al. Cellular Mechanisms Underlying Complete Hematological Response of Chronic Myeloid Leukemia to BRAF and MEK1/2 Inhibition in a Patient with Concomitant Metastatic Melanoma. Clin Cancer Res 21:5222-34 (2015). WB ; Human . PubMed: 26202951
  • Shai A  et al. TP53 Silencing Bypasses Growth Arrest of BRAFV600E-Induced Lung Tumor Cells in a Two-Switch Model of Lung Tumorigenesis. Cancer Res 75:3167-80 (2015). WB . PubMed: 26001956
  • Karachaliou N  et al. BIM and mTOR expression levels predict outcome to erlotinib in EGFR-mutant non-small-cell lung cancer. Sci Rep 5:17499 (2015). IHC ; Human . PubMed: 26639561
  • Ontikatze T  et al. Dihydroartemisinin is a Hypoxia-Active Anti-Cancer Drug in Colorectal Carcinoma Cells. Front Oncol 4:116 (2014). WB ; Human . PubMed: 24904829
  • Piazza R  et al. Epigenetic silencing of the proapoptotic gene BIM in anaplastic large cell lymphoma through an MeCP2/SIN3a deacetylating complex. Neoplasia 15:511-22 (2013). WB . PubMed: 23633923
  • Hug E  et al. Inducible expression of hyperactive Syk in B cells activates Blimp-1-dependent terminal differentiation. Oncogene N/A:N/A (2013). PubMed: 23955076
  • Pierceall WE  et al. BH3 profiling discriminates response to cytarabine-based treatment of acute myelogenous leukemia. Mol Cancer Ther 12:2940-9 (2013). Human . PubMed: 24092807
  • Marsh Durban V  et al. Differential AKT dependency displayed by mouse models of BRAFV600E-initiated melanoma. J Clin Invest 123:5104-18 (2013). WB ; Mouse . PubMed: 24200692
  • Séveno C  et al. ?-Secretase inhibition promotes cell death, Noxa upregulation, and sensitization to BH3 mimetic ABT-737 in human breast cancer cells. Breast Cancer Res 14:R96 (2012). PubMed: 22703841
  • Qi Y  et al. Bnip3 and AIF cooperate to induce apoptosis and cavitation during epithelial morphogenesis. J Cell Biol 198:103-14 (2012). ICC/IF . PubMed: 22753893
  • Sakuma Y  et al. WZ4002, a third-generation EGFR inhibitor, can overcome anoikis resistance in EGFR-mutant lung adenocarcinomas more efficiently than Src inhibitors. Lab Invest 92:371-83 (2012). Human . PubMed: 22157722
  • Brodin P  et al. Skewing of the NK cell repertoire by MHC class I via quantitatively controlled enrichment and contraction of specific Ly49 subsets. J Immunol 188:2218-26 (2012). Flow Cyt, ICC/IF ; Mouse . PubMed: 22287714
  • Oussaief L  et al. Activation of the lytic program of the Epstein-Barr virus in Burkitt's lymphoma cells leads to a two steps downregulation of expression of the proapoptotic protein BimEL, one of which is EBV-late-gene expression dependent. Virology 387:41-9 (2009). ICC/IF ; Human . PubMed: 19254802
  • Kochetkova M  et al. Chemokine receptors CXCR4 and CCR7 promote metastasis by preventing anoikis in cancer cells. Cell Death Differ 16:664-73 (2009). WB ; Human . PubMed: 19136936
  • Wilsbacher JL  et al. Insulin-like growth factor-1 receptor and ErbB kinase inhibitor combinations block proliferation and induce apoptosis through cyclin D1 reduction and Bax activation. J Biol Chem 283:23721-30 (2008). WB ; Human . PubMed: 18559346


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