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Western blot - BIN1 antibody (ab27796)
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Product Name
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BIN1 antibody
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See all BIN1 antibodies (5)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to BIN1
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Immunogen
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Synthetic peptide (Mouse) - corresponding to region surrounding amino acid 578 of mouse BIN 1.
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Reacts with
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Hu, Ms, Rat
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Tested applications
(see key)
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WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
WB: Use at a concentration of 0.5 - 2.0 µg/ml. Predicted molecular weight: 65 kDa and a 45kDa fragment can be detected in apoptotic samples.
Not yet tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Jurkat cells
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Cellular localization
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Cytoplasmic (Isoform IIa) and Nuclear (isoform BIN1)
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Research areas
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Cancer >> Oncoproteins/suppressors >> Tumor suppressors >> Other
Cancer >> Cell cycle >> Cell cycle inhibitors >> Other
Chromatin and Nuclear Signaling >> Cell cycle >> Cell Cycle Inhibitors >> Other
Chromatin and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Tumor Suppressors
Microbiology >> Interspecies Interaction >> Host Virus Interaction
Cell Biology >> Cell Cycle >> Cell Cycle Inhibitors >> Other
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Relevance
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The identification and analysis of tumor suppressors is of major importance for improved diagnosis and treatment of tumors. Bin1 (Box-dependent myc interacting protein 1, also known as SH3P9, amphiphysin II and amphl/amphiphysin-like) is a novel protein that has features of a tumor suppressor. Bin1 interacts with and inhibits the oncogenic activity of the myc oncoprotein that has a major role in many human cancers. The loss of Bin1 may contribute to growth deregulation in cancer cells in carcinoma of the breast, colon, lung, cervix, prostate and liver. Bin1 also interacts with HCV NS5A through its SH3 domain.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.02% Thimerosal (merthiolate)
Constituents: 20% Glycerol, 0.1% BSA, PBS Material safety datasheets (MSDS) for this product:
Glycerol MSDS
Thimerosal MSDS
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Form
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Liquid
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Concentration
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0.500 mg/ml
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Storage instructions
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Store at +4°C short term (1-2 weeks). Aliquot and store at -20°C long term. Avoid repeated freeze / thaw cycles.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this BIN1 antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for BIN1 antibody images, references, products related to ab27796 and other tools.
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BIN1 antibody images:
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Search PubMed (MEDLINE) for references to BIN1
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BIN1 antibody - more information
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Customer reviews (feedback) regarding BIN1 antibody |
Customer FAQs regarding BIN1 antibody |
Protocols for BIN1 antibody |
Price and availability of products related to BIN1 antibody |
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BIN1 antibody - related products:
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BIN1 antibody - other tools:
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Contact Abcam with a Technical Enquiry about BIN1 antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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Western blot - BIN1 antibody (ab27796)