Overview

  • Product name
    Bismuth subsalicylate
  • Description
    Prostaglandin G/H Synthase 1/2 inhibitor
  • Alternative names
    • Bismatrol
    • Bismusol
    • Bismuth oxysalicylate
    • Bismuth(III) salicylate basic
    • BSS
    • Kaopectate
    • Pepto-bismol
    • Subsalicylate bismuth
    see all
  • Biological description

    Used to treat temporary discomforts of the stomach and gastrointestinal tract, such as diarrhea, heartburn and nausea. Active ingredient in Pepto-Bismol. In the gastrointestinal tract, it is converted to salicylic acid and insoluble bismuth salts. Displays anti-inflammatory action (due to salicylic acid) and also acts as an antacid. Reduces inflammation/irritation of stomach and intestinal lining through inhibition of prostaglandin G/H Synthase 1/2. Antimicrobial properties against a wide-range of diarrhea-causing pathogens.

Properties

  • Chemical name
    2-Hydroxy-4H-1,3,2-benzodioxabismin-4-one
  • Molecular weight
    362.09
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C7H5BiO4
  • CAS Number
    14882-18-9
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Pitz AM  et al. Antimicrobial activity of bismuth subsalicylate on Clostridium difficile, Escherichia coli O157:H7, norovirus, and other common enteric pathogens. Gut Microbes 6:93-100 (2015). Read more (PubMed: 25901890) »
  • Sox TE & Olson CA Binding and killing of bacteria by bismuth subsalicylate. Antimicrob Agents Chemother 33:2075-82 (1989). Read more (PubMed: 2694949) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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