Overview

  • Product nameAnti-BLK antibody
    See all BLK primary antibodies
  • Description
    Goat polyclonal to BLK
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide:

    QWSPLKVSAQDKD

    by a C terminal Cysteine residue linker, corresponding to N terminal amino acids 22-34 of Human BLK (NP_001706.2).

  • Positive control
    • Human Thymus, Spleen and Lymph Node lysates.

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C. Avoid freeze / thaw cycles.
  • Storage bufferpH: 7.30
    Preservative: 0.02% Sodium azide
    Constituents: 99% Tris buffered saline, 0.5% BSA
  • Concentration information loading...
  • PurityImmunogen affinity purified
  • Purification notesab112542 was purified from Goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
  • ClonalityPolyclonal
  • IsotypeIgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab112542 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.1 - 0.3 µg/ml. Detects a band of approximately 50 kDa (predicted molecular weight: 58 kDa). Primary incubation: 1 hour.

Target

  • FunctionModulator of beta-cells function, acting through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.
  • Tissue specificityExpressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles.
  • Involvement in diseaseDefects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11) [MIM:613375]. MODY11 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
  • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
    Contains 1 protein kinase domain.
    Contains 1 SH2 domain.
    Contains 1 SH3 domain.
  • Information by UniProt
  • Database links
  • Alternative names
    • B lymphocyte kinase antibody
    • B lymphoid tyrosine kinase antibody
    • Blk antibody
    • BLK nonreceptor tyrosine kinase antibody
    • BLK_HUMAN antibody
    • EC 2.7.10.2 antibody
    • MGC 10442 antibody
    • MGC10442 antibody
    • MODY 11 antibody
    • MODY11 antibody
    • P55 BLK antibody
    • p55-BLK antibody
    • Tyrosine kinase B lymphocyte specific antibody
    • Tyrosine protein kinase antibody
    • Tyrosine-protein kinase BLK antibody
    see all

Anti-BLK antibody images

  • Anti-BLK antibody (ab112542) at 0.1 µg/ml + Human Thymus lysate (in RIPA buffer) at 35 µg
    Developed using the ECL technique

    Predicted band size : 58 kDa

References for Anti-BLK antibody (ab112542)

ab112542 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"