Overview

  • Product nameAnti-BLK antibody
    See all BLK primary antibodies
  • Description
    Mouse monoclonal to BLK
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Mouse, Human
  • Immunogen

    Recombinant fragment: MGLVSSKKPD KEKPIKEKDK GQWSPLKVSA QDKDAPPLPP LVVFNHLTPP PPDEHLDEDK HFVVALYDYT AMNDRDLQML KGEKLQVLKG , corresponding to amino acids 1-90 of Human BLK

Properties

  • FormLiquid
  • Storage instructionsShipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage bufferPreservative: None
    PBS, pH 7.2
  • Concentration information loading...
  • PurityProtein G purified
  • ClonalityMonoclonal
  • IsotypeIgG1
  • Light chain typekappa
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab54866 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionModulator of beta-cells function, acting through the up-regulation of PDX1 and NKX6-1 and consequent stimulation of insulin secretion in response to glucose.
    • Tissue specificityExpressed in lymphatic organs, pancreatic islets, Leydig cells, striate ducts of salivary glands and hair follicles.
    • Involvement in diseaseDefects in BLK are a cause of maturity-onset diabetes of the young type 11 (MODY11) [MIM:613375]. MODY11 is a form of diabetes that is characterized by an autosomal dominant mode of inheritance, onset in childhood or early adulthood (usually before 25 years of age), a primary defect in insulin secretion and frequent insulin-independence at the beginning of the disease.
    • Sequence similaritiesBelongs to the protein kinase superfamily. Tyr protein kinase family. SRC subfamily.
      Contains 1 protein kinase domain.
      Contains 1 SH2 domain.
      Contains 1 SH3 domain.
    • Information by UniProt
    • Database links
    • Alternative names
      • B lymphocyte kinase antibody
      • B lymphoid tyrosine kinase antibody
      • Blk antibody
      • BLK nonreceptor tyrosine kinase antibody
      • BLK_HUMAN antibody
      • EC 2.7.10.2 antibody
      • MGC 10442 antibody
      • MGC10442 antibody
      • MODY 11 antibody
      • MODY11 antibody
      • P55 BLK antibody
      • p55-BLK antibody
      • Tyrosine kinase B lymphocyte specific antibody
      • Tyrosine protein kinase antibody
      • Tyrosine-protein kinase BLK antibody
      see all

    Anti-BLK antibody images



    • Predicted band size : 58 kDa
      BLK antibody (ab54866) at 1ug/lane + Raw cell lysate at 25ug/lane.

    References for Anti-BLK antibody (ab54866)

    ab54866 has not yet been referenced specifically in any publications.

    Product Wall

    Thank you for your inquiry and I apologize for the delay in this reply as I was awaiting more information from the lab.   We don't have cross-reactivity data for ab54866. It has not been tested for cross-reactivity to Lck, Fyn, Lyn or any other Src ...

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"