The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
Use a concentration of 1 µg/ml. Predicted molecular weight: 16 kDa. Good results were obtained when blocked with 5% non-fat dry milk in 0.05% PBS-T.
FunctionMay play a role in cell proliferation. The BLOC-1 complex is required for normal biogenesis of lysosome-related organelles, such as platelet dense granules and melanosomes. Plays a role in intracellular vesicle trafficking.
Tissue specificityIsoform 1 and isoform 2 are widely expressed. Expressed in various malignant tumor tissues (at protein level).
Sequence similaritiesBelongs to the BLOC1S2 family.
Cellular localizationCytoplasm > cytoskeleton > centrosome. Localizes to the centrosomes in a microtubule-dependent manner.