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Tips and tricks to get your ChIP experiments working

To help you to get your ChIP experiments underway, we have brought some useful ChIP tips and tricks together in three articles that will make your experiments work first time and can be found on our epigenetics resources page.

  • If you want some help before you begin, the ChIP tips and tricks article, compiled by Dr Andy Bannister from the Gurdon Institute, will guide you through useful tips for a successful experiment.
  • If you are dealing with small sample sizes, have a look at our article on advances in ChIP-seq analysis with small samples for advice on the latest advances in ChIP-seq analysis.
  • If you are having trouble with high background, poor resolution or low signal, our ChIP troubleshooting guide will give you fixes to solve common ChIP problems.

View all epigenetics resources»


Top epigenetics articles | September

Too busy in the lab to keep on top of the latest epigenetics literature? Sit back and read our top picks from September.

Highlights of this month include how removal of the vernalized state in plants is achieved by epigenetic reprogramming, a role of histone variants in memory formation and advances in predicting epigenomes by studying DNA motifs.

View our September selection»


Free updated IHC application guide now available

There's a lot to think about when planning an IHC experiment, from what controls to use to which detection method is best. To support you, we gathered must-have IHC tips and tricks and updated our extensive IHC application guide. It covers the key steps and variables that you need to consider. These include:

  • Sample preparation
  • Antigen retrieval
  • Tissue permeabilization
  • Blocking and immunostaining
  • Key reagents

Get our IHC application guide»


Great new epigenetics funding opportunity from ESRC and BBSRC

"To encourage new, innovative and collaborative work between the social and biological sciences in the area of epigenetics."

The Economic and Social Research Council (ESRC) and Biotechnology and Biological Sciences Research Council (BBSRC) announced on Friday that they are calling for research projects in the field of social and Behavioral Epigenetics. Up to £3 million will be available for this call.

We think this is a really exciting opportunity that will enable scientists to explore the impact of epigenetics on interesting sociological and behavioral aspects of our lives.

For further information and networking opportunities, a one-day networking meeting is being held in London on November 5.

Find out more »


Protocols for your ChIP and epigenetics needs

Don't know where to start with your epigenetic sample preparation? Our epigenetic protocols and troubleshooting tips will support you during your experiments. Our protocols features popular epigenetic applications such as Chromatin Immunoprecipitation (ChIP), RIP, and CLIP and contain details of all the methods, materials and tips you need to successfully complete your experiments.

Browse epigenetics protocols »


A step-by-step guide to ChIP-seq data analysis | free webinar

Learn how to perform Chromatin immunoprecipitation followed by deep sequencing (ChIP-seq) routine analysis using a combination of different online tools available with guest speaker, Dr Xi Chen.

This webinar is ideal for researchers and students who are interested in ChIP-seq data analysis. It is particularly useful for those who are planning to learn unix command line to process many sequencing data sets in the future.

Register now »


Applications of ChIP | free webinar

Interested in Epigenetics, ChIP and histone modifications? This webinar chaired by Dr David Grotsky will take you through introduction to ChIP and its applications while highlighting relevant publications.

Our speaker will cover:

  • An introduction to chromatin and ChIP
  • The histone code hypothesis
  • What we learn from ChIP-on-chip
  • What we learn from ChIP-seq
  • Variations of ChIP

You will also be able to submit questions for our speaker.

This webinar is ideal for PhD students, researchers and people with an interest in Epigenetics, ChIP and histone modifications.

Register now »


Scientist of the month | interview with Robert Schneider

Every month we interview a scientist who has made a significant contribution to epigenetics research, as part of our Scientist of the Month series.

Next in the series is Robert Schneider, from the Institute of Genetics and Molecular and Cellular Biology (IGBMC) in Strasbourg, who tells us about recent developments in his lab including exciting new research looking at epigenetic processes in individual living cells. Rob is also chairing our upcoming conference, Chromatin and Epigenetics: From Omics to Single Cells, and tells us more about what we can expect from the meeting.

Read the full Interview »


Top epigenetics articles | August

We have scoured the latest epigenetics literature to bring you our favorite papers published throughout August.

Highlights this month include an epigenome-wide study of brain tissue from patients with Alzheimer's disease, the effect of fetal alcohol exposure on heart development and a new ChIP protocol optimized for woody plant tissues.

View our August selection »


Watch our ChIP step-by-step webinar

If you missed out on the webinar, you can now watch it for free.

Learn about chromatin immunoprecipitation (ChIP) techniques in our latest webinar chaired by epigenetics specialist Dr Katarzyna Dudek.

Our speaker covers:

  • What is ChIP?
  • What is chromatin?
  • Histones
  • Different types of ChIP
  • ChIP protocol: chromatin preparation, sonication, immunoprecipitation, cross-linking reversion and DNA purification, DNA analysis and necessary controls

This webinar is ideal for PhD students, researchers and people with an interest in getting a comprehensive understanding of the ChIP technique.

Watch webinar »


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