Overview

Properties

Applications

Our Abpromise guarantee covers the use of ab34962 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/50 - 1/200.
Competitive ELISA 1/10000.

Target

  • Function
    Required for maintaining the proliferative activity of embryonic cardiomyocytes by preventing premature activation of the negative cell cycle regulator CDKN1C/p57KIP and maintaining the required expression levels of cardiogenic factors such as MEF2C and NKX2-5. Acts as a ligand for ACVRL1/ALK1, BMPR1A/ALK3 and BMPR1B/ALK6, leading to activation of SMAD1, SMAD5 and SMAD8 transcription factors. Inhibits endothelial cell migration and growth.
  • Sequence similarities
    Belongs to the TGF-beta family.
  • Cellular localization
    Secreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • BMP-10 antibody
    • Bmp10 antibody
    • BMP10_HUMAN antibody
    • Bone morphogenetic protein 10 antibody
    • Bone morphogenetic protein 10 preproprotein antibody
    • MGC126783 antibody
    • OTTHUMP00000159973 antibody
    see all

References

ab34962 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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