Anti-BMP15 antibody [EPR5137] (ab108413)
- Datasheet
- Specific References (1)
- Protocols
Overview
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Product nameAnti-BMP15 antibody [EPR5137]
See all BMP15 primary antibodies -
DescriptionRabbit monoclonal [EPR5137] to BMP15
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Host speciesRabbit
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Tested applicationsSuitable for: WB, Flow Cytmore details
Unsuitable for: ICC,IHC-P or IP -
Species reactivityReacts with: Mouse, Rat, Human
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Immunogen
Synthetic peptide within Human BMP15 aa 350-450 (C terminal). The exact sequence is proprietary.
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Positive control
- Ovary cancer, uterus, HL-60, NIH:OVCAR-3, Human testis, and HeLa cell lysates; Hela cells
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General notes
Our RabMAb® technology is a patented hybridoma-based technology for making rabbit monoclonal antibodies. For details on our patents, please refer to RabMab® patents
This product is a recombinant rabbit monoclonal antibody.
Properties
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FormLiquid
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Storage instructionsShipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
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Dissociation constant (KD)KD = 8.80 x 10 -11 M Learn more about KD
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Storage bufferPBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
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PurityTissue culture supernatant
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ClonalityMonoclonal
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Clone numberEPR5137
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IsotypeIgG
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Research areas
Applications
Our Abpromise guarantee covers the use of ab108413 in the following tested applications.
The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
| Application | Abreviews | Notes |
|---|---|---|
| WB | 1/1000 - 1/10000. Predicted molecular weight: 45 kDa. | |
| Flow Cyt | 1/10 - 1/100. ab172730 - Rabbit monoclonal IgG, is suitable for use as an isotype control with this antibody.
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Target
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FunctionMay be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
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Involvement in diseaseDefects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2) [MIM:300510]; also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea.
Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4) [MIM:300510]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol. -
Sequence similaritiesBelongs to the TGF-beta family.
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Cellular localizationSecreted.
- Information by UniProt
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Database links
- Entrez Gene: 9210 Human
- Entrez Gene: 12155 Mouse
- Entrez Gene: 59302 Rat
- Omim: 300247 Human
- SwissProt: O95972 Human
- SwissProt: Q9Z0L4 Mouse
- Unigene: 532692 Human
- Unigene: 42160 Mouse
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Alternative names
- BMP 15 antibody
- BMP-15 antibody
- BMP15 antibody
see all
Images
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![Western blot - Anti-BMP15 antibody [EPR5137] (ab108413)](http://a.abcam.com/ps/products/108/ab108413/Images/BMP15-Primary-antibodies-ab108413-1.jpg)
Western blot - Anti-BMP15 antibody [EPR5137] (ab108413)All lanes : Anti-BMP15 antibody [EPR5137] (ab108413) at 1/1000 dilution
Lane 1 : Ovary cancer lysate
Lane 2 : Uterus lysate
Lane 3 : HL-60 cell lysate
Lane 4 : NIH:OVCAR-3 cell lysate
Lane 5 : Human testis lysate
Lane 6 : HeLa cell lysate
Lysates/proteins at 10 µg per lane.
Predicted band size: 45 kDa -
![Flow Cytometry - Anti-BMP15 antibody [EPR5137] (ab108413)](http://a.abcam.com/ps/products/108/ab108413/Images/BMP15-Primary-antibodies-ab108413-2.jpg)
Flow Cytometry - Anti-BMP15 antibody [EPR5137] (ab108413)Flow cytometric analysis of BMP15 in permeabilized Hela cells using ab108413 at 1/10 dilution (red) or a rabbit IgG (negative) (green). -
![Other - Anti-BMP15 antibody [EPR5137] (ab108413)](http://a.abcam.com/ps/products/108/ab108413/Images/BMP15-Primary-antibodies-ab108413-3.jpg)
Other - Anti-BMP15 antibody [EPR5137] (ab108413)
References
This product has been referenced in:
- Pelosi E et al. Constitutively active Foxo3 in oocytes preserves ovarian reserve in mice. Nat Commun 4:1843 (2013). Mouse . Read more (PubMed: 23673628) »
Customer reviews and Q&As
Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"