Anti-BMP15 antibody [EPR5137] (ab108413)

Overview

• Product name
  Anti-BMP15 antibody [EPR5137]
  See all BMP15 primary antibodies
• Description
  Rabbit monoclonal [EPR5137] to BMP15
• Tested applications
  Suitable for: WB, Flow Cytmore details
  Unsuitable for: ICC,IHC-P or IP
• Species reactivity
  Reacts with: Mouse, Rat, Human
  
• Immunogen

  Synthetic peptide corresponding to residues near the C terminus of Human BMP15.

• Positive control
  • Ovary cancer, uterus, HL-60, NIH:OVCAR-3, Human testis, and HeLa cell lysates; Hela cells
• General notes

  This product is a recombinant rabbit monoclonal antibody.

  Produced using Abcam’s RabMAb^® technology. RabMAb^® technology is covered by the following U.S. Patents, No. 5,675,063 and/or 7,429,487.

Properties

• Form
  Liquid
• Storage instructions
  Shipped at 4°C. Store at -20°C. Stable for 12 months at -20°C.
• Dissociation constant (K_D)
  K_D = 8.80 x 10 ^-11 M Learn more about K_D
• Storage buffer
  PBS 49%,Sodium azide 0.01%,Glycerol 50%,BSA 0.05%
• Purity
  Tissue culture supernatant
• Clonality
  Monoclonal
• Clone number
  EPR5137
• Isotype
  IgG
• Research areas
  • Cardiovascular
  • Angiogenesis
  • Growth Factors
  • TGF

  • Signal Transduction
  • Growth Factors/Hormones
  • TGF

  • Stem Cells
  • Germline Stem Cells
  • Embryonic Germ Cells

  • Stem Cells
  • Signaling Pathways
  • TGF beta
  • Secreted

  • Developmental Biology
  • Reproduction
  • Germ cell markers

Applications

Target

• Function
  May be involved in follicular development. Oocyte-specific growth/differentiation factor that stimulates folliculogenesis and granulosa cell (GC) growth.
• Involvement in disease
  Defects in BMP15 are the cause of ovarian dysgenesis type 2 (ODG2) [MIM:300510]; also known as X-linked hypergonadotropic ovarian dysgenesis or hypergonadotropic ovarian failure due to ovarian dysgenesis. Ovarian dysgenesis leads to ovarian failure and accounts for about half of the cases of primary amenorrhea.
  Defects in BMP15 are the cause of premature ovarian failure type 4 (POF4) [MIM:300510]. An ovarian disorder defined as the cessation of ovarian function under the age of 40 years. It is characterized by oligomenorrhea or amenorrhea, in the presence of elevated levels of serum gonadotropins and low estradiol.
• Sequence similarities
  Belongs to the TGF-beta family.
• Cellular localization
  Secreted.

• Target information above from: UniProt accession O95972 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 9210 Human
  • Entrez Gene: 12155 Mouse
  • Entrez Gene: 59302 Rat
  • Omim: 300247 Human
  • SwissProt: O95972 Human
  • SwissProt: Q9Z0L4 Mouse
  • Unigene: 532692 Human
  • Unigene: 42160 Mouse
• Alternative names
  • BMP 15 antibody
  • BMP-15 antibody
  • BMP15 antibody

  • BMP15_HUMAN antibody
  • Bone morphogenetic protein 15 antibody
  • GDF 9B antibody
  • GDF-9B antibody
  • GDF9B antibody
  • Growth/differentiation factor 9B antibody
  • ODG2 antibody
  • POF4 antibody

  see all

Protocols

• Western blot protocols
• Flow cytometry protocols