Overview

  • Product nameAnti-BMP4 antibody, prediluted
    See all BMP4 primary antibodies
  • Description
    Rabbit polyclonal to BMP4, prediluted
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant full length protein: human BMP4

  • Positive control
    • Bone marrow

Properties

Applications

Our Abpromise guarantee covers the use of ab31166 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/1 for 30 min at RT. Perform heat mediated antigen retrieval via the pressure cooker method before commencing with IHC staining protocol, by boiling tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionInduces cartilage and bone formation. Also act in mesoderm induction, tooth development, limb formation and fracture repair. Acts in concert with PTHLH/PTHRP to stimulate ductal outgrowth during embryonic mammary development and to inhibit hair follicle induction.
    • Tissue specificityExpressed in the lung and lower levels seen in the kidney. Present also in normal and neoplastic prostate tissues, and prostate cancer cell lines.
    • Involvement in diseaseDefects in BMP4 are the cause of microphthalmia syndromic type 6 (MCOPS6) [MIM:607932]; also known as microphthalmia and pituitary anomalies or microphthalmia with brain and digit developmental anomalies. Microphthalmia is a clinically heterogeneous disorder of eye formation, ranging from small size of a single eye to complete bilateral absence of ocular tissues (anophthalmia). In many cases, microphthalmia/anophthalmia occurs in association with syndromes that include non-ocular abnormalities. MCOPS6 is characterized by microphthalmia/anophthalmia associated with facial, genital, skeletal, neurologic and endocrine anomalies.
      Defects in BMP4 are the cause of non-syndromic orofacial cleft type 11 (OFC11) [MIM:600625]. Non-syndromic orofacial cleft is a common birth defect consisting of cleft lips with or without cleft palate. Cleft lips are associated with cleft palate in two-third of cases. A cleft lip can occur on one or both sides and range in severity from a simple notch in the upper lip to a complete opening in the lip extending into the floor of the nostril and involving the upper gum. OFC11 is an unusual anomaly consisting of a paramedian scar of the upper lip with an appearance suggesting that a typical cleft lip was corrected in utero.
    • Sequence similaritiesBelongs to the TGF-beta family.
    • Cellular localizationSecreted > extracellular space > extracellular matrix.
    • Information by UniProt
    • Database links
    • Alternative names
      • zgc:100779 antibody
      • BMP 2B antibody
      • BMP 4 antibody
      • BMP-2B antibody
      • BMP-4 antibody
      • BMP2B antibody
      • BMP2B1 antibody
      • BMP4 antibody
      • BMP4_HUMAN antibody
      • Bone morphogenetic protein 2B antibody
      • Bone morphogenetic protein 4 antibody
      • DVR4 antibody
      • MCOPS6 antibody
      • MGC100779 antibody
      • OFC11 antibody
      • zbmp-4 antibody
      • ZYME antibody
      see all

    Anti-BMP4 antibody, prediluted images

    • Human bone marrow stained with anti-BMP4 (ab31166, pre-diluted).

    References for Anti-BMP4 antibody, prediluted (ab31166)

    ab31166 has not yet been referenced specifically in any publications.

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    There are currently no Abreviews or Questions for ab31166.
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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"