General notesab94187 is a 293T cell transfected lysate in which Human BMP7 has been transiently over-expressed using a pCMV-BMP7 plasmid. The lysate is provided in 1X Sample Buffer.
Note: For more details about how the transfected lysate was prepared view the preparation notes.
BackgroundFunction: Induces cartilage and bone formation. May be the osteoinductive factor responsible for the phenomenon of epithelial osteogenesis. Plays a role in calcium regulation and bone homeostasis.
Tissue specificity: Expressed in the kidney and bladder. Lower levels seen in the brain.
Similarity: Belongs to the TGF-beta family.
Developmental stage: Expressed in the developing eye, brain and ear during embryogenesis.
PTM: Several N-termini starting at positions 293, 300, 315 and 316 have been identified by direct sequencing resulting in secretion of different mature forms (PubMed:17977014).