Overview

  • Product name
    BMY 7378 dihydrochloride
  • Description
    5-HT1A partial agonist. α adrenoceptor antagonist.
  • Biological description
    5-HT1A partial agonist (IC50 = 0.8 nM). Potent and selective α1D adrenoceptor antagonist (Ki values are 2, 600 and 800 nM at α1D, α1B and α1A receptors, respectively). Shows antihypertensive activity.
  • Purity
    > 99%

Properties

References

This product has been referenced in:
  • Piascik MT  et al. The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J Pharmacol Exp Ther 275:1583-9 (1995). Read more (PubMed: 8531132) »
  • Ahlers ST  et al. Antagonism studies with BMY-7378 and NAN-190: effects on 8-hydroxy-2-(di-n-propylamino)tetralin-induced increases in punished responding of pigeons. J Pharmacol Exp Ther 260:474-81 (1992). Read more (PubMed: 1531359) »
  • Villalobos-Molina R  et al. The hypotensive effect of BMY 7378 involves central 5-HT1A receptor stimulation in the adult but not in the young rat. Arch Med Res 35:495-8 (0). Read more (PubMed: 15631873) »

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