Biological description5-HT1A partial agonist (IC50 = 0.8 nM). Potent and selective α1D adrenoceptor antagonist (Ki values are 2, 600 and 800 nM at α1D, α1B and α1A receptors, respectively). Shows antihypertensive activity.
Chemical name8-[2-[4-(2-Methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspirol[4,5]decane-7,9-dione dihydrochloride
Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
Solubility overviewSoluble in water to 100 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for BMY 7378 dihydrochloride (ab120520)
This product has been referenced in:
Piascik MT et al. The specific contribution of the novel alpha-1D adrenoceptor to the contraction of vascular smooth muscle. J Pharmacol Exp Ther275:1583-9 (1995).
Read more (PubMed: 8531132) »
Ahlers ST et al. Antagonism studies with BMY-7378 and NAN-190: effects on 8-hydroxy-2-(di-n-propylamino)tetralin-induced increases in punished responding of pigeons. J Pharmacol Exp Ther260:474-81 (1992).
Read more (PubMed: 1531359) »
Villalobos-Molina R et al. The hypotensive effect of BMY 7378 involves central 5-HT1A receptor stimulation in the adult but not in the young rat. Arch Med Res35:495-8 (0).
Read more (PubMed: 15631873) »