Overview

  • Product name
  • Description
    Rabbit polyclonal to BNIP3L
  • Host species
    Rabbit
  • Tested applications
    Suitable for: WB, IHC-P, ICC/IFmore details
  • Species reactivity
    Reacts with: Mouse, Human
    Predicted to work with: Rat, Chicken, Cow, Monkey
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 95-189 of Human BNIP3L (Uniprot ID O60238)

  • Positive control
    • HeLa cells; Molt-4 whole cell lysate; Raji cells; mouse liver whole cell lysate; Human Colon cancer

Properties

Applications

Our Abpromise guarantee covers the use of ab155010 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 24 kDa.
IHC-P 1/100 - 1/1000.
ICC/IF 1/100 - 1/1000.

Target

  • Function
    Induces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. May function as a tumor suppressor. Inhibits apoptosis induced by BNIP3.
  • Sequence similarities
    Belongs to the NIP3 family.
  • Post-translational
    modifications
    Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.
  • Cellular localization
    Nucleus envelope. Endoplasmic reticulum. Mitochondrion. Membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • Adenovirus E1B19k binding protein B5 antibody
    • Adenovirus E1B19K-binding protein B5 antibody
    • BCL2/adenovirus E1B 19 kd protein interacting protein 3a antibody
    • BCL2/adenovirus E1B 19 kDa protein interacting protein 3A antibody
    • BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like antibody
    • BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A antibody
    • BCL2/adenovirus E1B 19kDa interacting protein 3 like antibody
    • BNI3L_HUMAN antibody
    • BNIP3a antibody
    • BNIP3H antibody
    • BNIP3L antibody
    • BNIP3L protein antibody
    • NIP3 like protein X antibody
    • NIP3-like protein X antibody
    • NIP3L antibody
    • NIX antibody
    see all

Images

  • Anti-BNIP3L antibody (ab155010) at 1/1000 dilution + Molt4 whole cell lysate at 30 µg

    Predicted band size: 24 kDa



    12% SDS PAGE
  • Anti-BNIP3L antibody (ab155010) at 1/500 dilution + mouse liver whole cell lysate at 50 µg

    Predicted band size: 24 kDa



    12% SDS PAGE
  • Immunohistochemical analysis of paraffin-embedded Human colon cancer labeling BNIP3L with ab155010 antibody at 1/500 dilution.
  • Immunofluorescent analysis of methanol-fixed HeLa cells labeling BNIP3L with ab155010 antibody at 1/200 dilution. Bottom figure: staining merged with DNA probe (Hoechst 33342).

References

ab155010 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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