Overview

Description

  • NatureSynthetic

Associated products

Specifications

Our Abpromise guarantee covers the use of ab8431 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Western blot

    Blocking

  • FormLiquid
  • Additional notes

    1. Chen G, Cizeau J, Vande Velde C, et al. Nix and Nip3 form a subfamily of pro-apoptoticmitochondrial proteins. J Biol Chem (1999) 274(1):7-10.

  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    PBS with 0.1% BSA 0.02% sodium azide pH7.2

General Info

  • Alternative names
    • Adenovirus E1B19k binding protein B5
    • Adenovirus E1B19K-binding protein B5
    • BCL2/adenovirus E1B 19 kd protein interacting protein 3a
    • BCL2/adenovirus E1B 19 kDa protein interacting protein 3A
    • BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
    • BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A
    • BCL2/adenovirus E1B 19kDa interacting protein 3 like
    • BNI3L_HUMAN
    • BNIP3a
    • BNIP3H
    • BNIP3L
    • BNIP3L protein
    • NIP3 like protein X
    • NIP3-like protein X
    • NIP3L
    • NIX
    see all
  • FunctionInduces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. May function as a tumor suppressor. Inhibits apoptosis induced by BNIP3.
  • Sequence similaritiesBelongs to the NIP3 family.
  • Post-translational
    modifications
    Undergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.
  • Cellular localizationNucleus envelope. Endoplasmic reticulum. Mitochondrion. Membrane.
  • Information by UniProt

References for BNIP3L peptide (ab8431)

ab8431 has not yet been referenced specifically in any publications.

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