The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.
1. Chen G, Cizeau J, Vande Velde C, et al. Nix and Nip3 form a subfamily of pro-apoptoticmitochondrial proteins. J Biol Chem (1999) 274(1):7-10.
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Preparation and Storage
Stability and Storage
Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
PBS with 0.1% BSA 0.02% sodium azide pH7.2
Adenovirus E1B19k binding protein B5
Adenovirus E1B19K-binding protein B5
BCL2/adenovirus E1B 19 kd protein interacting protein 3a
BCL2/adenovirus E1B 19 kDa protein interacting protein 3A
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3-like
BCL2/adenovirus E1B 19 kDa protein-interacting protein 3A
BCL2/adenovirus E1B 19kDa interacting protein 3 like
NIP3 like protein X
NIP3-like protein X
FunctionInduces apoptosis. Interacts with viral and cellular anti-apoptosis proteins. Can overcome the suppressors BCL-2 and BCL-XL, although high levels of BCL-XL expression will inhibit apoptosis. May function as a tumor suppressor. Inhibits apoptosis induced by BNIP3.
Sequence similaritiesBelongs to the NIP3 family.
Post-translational modificationsUndergoes progressive proteolysis to an 11 kDa C-terminal fragment, which is blocked by the proteasome inhibitor lactacystin.