Anti-BOB1 antibody [SP92], prediluted (ab100903)

Overview

• Product name
  Anti-BOB1 antibody [SP92], prediluted
  See all BOB1 primary antibodies
• Description
  Rabbit monoclonal [SP92] to BOB1, prediluted
• Tested applications
  Suitable for: WB, IHC-Pmore details
• Species reactivity
  Reacts with: Human
  
• Immunogen

  Synthetic peptide derived from the C terminal region of Human BOB1

• Positive control
  • Human tonsil tissue
• General notes

  This product is a recombinant rabbit monoclonal antibody.

Properties

• Form
  Prediluted
• Storage instructions
  Shipped at 4°C. Store at +4°C.
• Storage buffer
  Preservative: 0.1% Sodium Azide
  Constituents: 1% BSA, 50mM Tris, pH 7.6
• Concentration information loading...
• Purity
  IgG fraction
• Clonality
  Monoclonal
• Clone number
  SP92
• Isotype
  IgG
• Research areas
  • Immunology
  • Adaptive Immunity
  • B Cells
  • Non-CD

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • Developmental Families
  • POU

Applications

Target

• Function
  Transcriptional coactivator that specifically associates with either OCT1 or OCT2. It boosts the OCT1 mediated promoter activity and to a lesser extent, that of OCT2. It has no intrinsic DNA-binding activity. It recognizes the POU domains of OCT1 and OCT2. It is essential for the response of B-cells to antigens and required for the formation of germinal centers.
• Tissue specificity
  B-cell specific.
• Involvement in disease
  Note=A chromosomal aberration involving POU2AF1/OBF1 may be a cause of a form of B-cell leukemia. Translocation t(3;11)(q27;q23) with BCL6.
• Sequence similarities
  Belongs to the POU2AF1 family.
• Post-translational
  modifications
  Ubiquitinated; mediated by SIAH1 or SIAH2 and leading to its subsequent proteasomal degradation.
• Cellular localization
  Nucleus.

• Target information above from: UniProt accession Q16633 The UniProt Consortium
  The Universal Protein Resource (UniProt) in 2010
  Nucleic Acids Res. 38:D142-D148 (2010) .

  Information by UniProt
• Database links
  • Entrez Gene: 5450 Human
  • Omim: 601206 Human
  • SwissProt: Q16633 Human
  • Unigene: 654525 Human
• Alternative names
  • B cell Oct binding protein 1 antibody
  • B cell specific coactivator OBF 1 antibody
  • B cell specific coactivator OBF1 antibody

  • B-cell-specific coactivator OBF-1 antibody
  • BOB 1 antibody
  • BOB-1 antibody
  • OBF 1 antibody
  • OBF1 antibody
  • OBF1_HUMAN antibody
  • OCA B antibody
  • OCA-B antibody
  • OCAB antibody
  • OCT binding factor 1 antibody
  • OCT-binding factor 1 antibody
  • POU class 2 associating factor 1 antibody
  • POU domain class 2 associating factor 1 antibody
  • POU domain class 2-associating factor 1 antibody
  • Pou2af1 antibody

  see all

Protocols

• Western blot protocols
• Immunohistochemistry protocols