Overview

  • Product name
  • Description
    Rabbit polyclonal to Bok
  • Specificity
    The antibody detects the 18 kDa recombinant rat BOK expressed in E.coli.
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Rat
  • Immunogen

    Synthetic peptide: corresponding to amino acids 41-61 of Bok

  • General notes


    Bok (Bcl-2-related ovarian killer) is a pro-apoptotic Bcl-2 family protein identified in the ovary based on its dimerization with the anti-apoptotic protein Mcl-1. In addition to the Bcl-2 homology (BH) domains 1 and 2 and the transmembrane sequence, Bok also has a BH3 domain believed to be important for dimerization with selective anti-apoptotic Bcl-2 proteins and cell killing. Bok interacts strongly with some (Mcl-1, BHRF1, and Bfl-1) but not other (Bcl-2, Bcl-xL, and Bcl-w) anti-apoptotic members. In addition, cell killing induced by Bok was suppressed following coexpression with Mcl-1 and BHRF1, but not with Bcl-2, further indicating that Bok heterodimerized only with selective anti-apoptotic Bcl-2 proteins. Bok was highly expressed in the ovary, testis and uterus.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
  • Storage buffer
    Preservative: 0.02% Thimerosal (merthiolate)
    Constituents: 50% Glycerol, 1% BSA, PBS, pH 7.2
  • Concentration information loading...
  • Purity
    Immunogen affinity purified
  • Primary antibody notes
    Bok (Bcl-2-related ovarian killer) is a pro-apoptotic Bcl-2 family protein identified in the ovary based on its dimerization with the anti-apoptotic protein Mcl-1. In addition to the Bcl-2 homology (BH) domains 1 and 2 and the transmembrane sequence, Bok also has a BH3 domain believed to be important for dimerization with selective anti-apoptotic Bcl-2 proteins and cell killing. Bok interacts strongly with some (Mcl-1, BHRF1, and Bfl-1) but not other (Bcl-2, Bcl-xL, and Bcl-w) anti-apoptotic members. In addition, cell killing induced by Bok was suppressed following coexpression with Mcl-1 and BHRF1, but not with Bcl-2, further indicating that Bok heterodimerized only with selective anti-apoptotic Bcl-2 proteins. Bok was highly expressed in the ovary, testis and uterus.
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab2304 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 - 2 µg/ml.

Target

  • Function
    May play a role in apoptosis.
  • Tissue specificity
    Expressed in brain, liver, appendix and lymphoid tissues.
  • Sequence similarities
    Belongs to the Bcl-2 family.
  • Information by UniProt
  • Database links
  • Alternative names
    • Bcl 2 related ovarian killer protein antibody
    • Bcl-2-like protein 9 antibody
    • Bcl-2-related ovarian killer protein antibody
    • BCL2 related ovarian killer antibody
    • Bcl2-L-9 antibody
    • BCL2L9 antibody
    • BOK antibody
    • BOK_HUMAN antibody
    • BOKL antibody
    • Hbok antibody
    • MGC4631 antibody
    see all

References

This product has been referenced in:
  • Siu PM & Alway SE Mitochondria-associated apoptotic signalling in denervated rat skeletal muscle. J Physiol 565:309-23 (2005). WB ; Rat . Read more (PubMed: 15774533) »

See 1 Publication for this product

Customer reviews and Q&As

The supplier of ab2304 has informed me that the immunogen is not available to purchase. If you have any more questions, please contact us again.

Ab2304 is an antibody that we do not make in-house and instead source from another company. I have enquired with the supplier of ab2304 to see if it is an option for you to purchase it. As soon as I hear back from the supplier I will let you know.

The immunogen is a.a. 41-61 of rat Bok.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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