Anti-Bone Alkaline Phosphatase antibody (ab68716)

Overview

  • Product name
    Anti-Bone Alkaline Phosphatase antibody
  • Description
    Sheep polyclonal to Bone Alkaline Phosphatase
  • Tested applications
    Suitable for: ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native protein from native human bone(purified)

Properties

Applications

Our Abpromise guarantee covers the use of ab68716 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/500 - 1/2500.

Target

  • Function
    This isozyme may play a role in skeletal mineralization.
  • Involvement in disease
    Defects in ALPL are a cause of hypophosphatasia (HOPS) [MIM:241500]. HOPS is an inherited metabolic bone disease characterized by defective skeletal mineralization. Four hypophosphatasia forms are distinguished, depending on the age of onset: perinatal, infantile, childhood [MIM:241510] and adult [MIM:146300] type. The perinatal form is the most severe and is almost always fatal. Patients with only premature loss of deciduous teeth, but with no bone disease are regarded as having odontohypophosphatasia (odonto).
  • Sequence similarities
    Belongs to the alkaline phosphatase family.
  • Post-translational
    modifications
    Glycosylated.
  • Cellular localization
    Cell membrane.
  • Information by UniProt
  • Database links
  • Alternative names
    • AKP2 antibody
    • Alkaline phosphatase antibody
    • Alkaline phosphatase liver/bone/kidney isozyme antibody
    • Alpl antibody
    • AP-TNAP antibody
    • HOPS antibody
    • Liver/bone/kidney isozyme antibody
    • PHOA antibody
    • PPBT_HUMAN antibody
    • Tissue non specific alkaline phosphatase antibody
    • Tissue nonspecific ALP antibody
    • tissue-nonspecific isozyme antibody
    • TNAP antibody
    • TNSALP antibody
    see all

References

ab68716 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

These two antibodies recognize primarily Bone Alkaline Phosphatase, but they do cross react with intestinal, placental, liver and kidney AP to a lesser extent.  
I hope this is helpful. Please contact us again if you have any further questions.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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