Overview

  • Product name
  • Description
    Rabbit polyclonal to BPGM
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide conjugated to KLH, corresponding to a region within C terminal amino acids 229-259 of Human BPGM (NP_001715.1 , NP_954655.1).

  • Positive control
    • MDA-MB-435 cell lysate; 293 cell lysate transiently transfected with BPGM

Properties

Applications

Our Abpromise guarantee covers the use of ab112957 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/100 - 1/500. Predicted molecular weight: 30 kDa.

Target

  • Function
    Plays a major role in regulating hemoglobin oxygen affinity by controlling the levels of 2,3-bisphosphoglycerate (2,3-BPG). Also exhibits mutase (EC 5.4.2.1) and phosphatase (EC 3.1.3.13) activities.
  • Involvement in disease
    Defects in BPGM are the cause of bisphosphoglycerate mutase deficiency (BPGMD) [MIM:222800]. A disease characterized by hemolytic anemia, splenomegaly, cholelithiasis and cholecystitis.
  • Sequence similarities
    Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.
  • Post-translational
    modifications
    Glycation of Lys-159 in diabetic patients inactivates the enzyme.
  • Information by UniProt
  • Database links
  • Alternative names
    • 2 antibody
    • 2,3-bisphosphoglycerate mutase antibody
    • 2,3-bisphosphoglycerate mutase, erythrocyte antibody
    • 2,3-bisphosphoglycerate synthase antibody
    • 2,3-diphosphoglycerate mutase antibody
    • 3-bisphosphoglycerate mutase antibody
    • 3-bisphosphoglycerate synthase antibody
    • 3-diphosphoglycerate mutase antibody
    • Ab2 098 antibody
    • AI323730 antibody
    • AL022789 antibody
    • Bisphosphoglycerate mutase antibody
    • BPG dependent PGAM antibody
    • BPG-dependent PGAM antibody
    • Bpgm antibody
    • C86192 antibody
    • DPGM antibody
    • Erythrocyte 2,3 bisphosphoglycerate mutase antibody
    • erythrocyte antibody
    • PMGE_HUMAN antibody
    see all

Images

  • Anti-BPGM antibody (ab112957) at 1/100 dilution + MDA-MB-435 cell lysate at 35 µg

    Predicted band size : 30 kDa
  • All lanes : Anti-BPGM antibody (ab112957) at 1/100 dilution

    Lane 1 : Nontransfected 293 cell lysate
    Lane 2 : 293 cell lysate transiently transfected with the BPGM gene

    Lysates/proteins at 2 µg per lane.


    Predicted band size : 30 kDa

References

ab112957 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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