Overview

  • Product nameAnti-BPTF / FALZ antibody
    See all BPTF / FALZ primary antibodies
  • Description
    Rabbit polyclonal to BPTF / FALZ
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region within amino acids 1350-1400 of Human BPTF/ FALZ (NP_872579.2).

  • Positive control
    • Human Breast Carcinoma, Colon Carcinoma, Ovarian Carcinoma, Prostate Carcinoma and Testicular Seminoma tissues.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab99399 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with tris-EDTA pH9.0 buffer will enhance staining.

Target

  • RelevanceBPTF (bromodomain and PHD domain transcription factor) is the largest subunit of the ATP-dependent chromatin-remodelling complex, NURF (nucleosome remodelling factor). NURF catalyses ATP-dependent nucleosome sliding and facilitates transcription. BPTF recognises histone H3 tails that are tri-methylated at K4, which marks the transcriptional start site of the vast majority of transcriptionally active genes. BPTF also exhibits some binding to H3 di-methylated at K4. BPTF plays a key role in the development of early mouse embryos, possibly through regulation of the Smad pathway of transcription factors. While BPTF is expressed in low levels in the adult brain and spinal cord, it is expressed in higher levels in the brain in neurodegenerative diseases. It is present in a subset of amyloid-containing plaques in the brains of patients suffering from Alzheimer's disease.
  • Cellular localizationCytoplasmic and Nuclear
  • Database links
  • Alternative names
    • Bromodomain and PHD finger containing transcription factor antibody
    • Bromodomain PHD finger transcription factor antibody
    • FAC 1 antibody
    • fac1 antibody
    • FALZ antibody
    • Fetal Alz 50 clone 1 protein antibody
    • Fetal Alz 50 reactive clone 1 antibody
    • Fetal Alzheimer antigen antibody
    • Nucleosome remodeling factor antibody
    • Nucleosome remodeling factor subunit BPTF antibody
    • Nucleosome remodeling factor, large subunit antibody
    • NURF 301 antibody
    • NURF301 antibody
    see all

Anti-BPTF / FALZ antibody images

  • ab99399, at 1/250 dilution, staining BPTF / FALZ in formalin-fixed, paraffin-embedded Human breast carcinoma by Immunohistochemistry. Detection: DAB staining.
  • ab99399, at 1/250 dilution, staining BPTF / FALZ in formalin-fixed, paraffin-embedded Human colon carcinoma by Immunohistochemistry. Detection: DAB staining.

References for Anti-BPTF / FALZ antibody (ab99399)

ab99399 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab99399.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"