Overview

  • Product name
  • Description
    Rabbit polyclonal to BRD7
  • Tested applications
    Suitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Chimpanzee, Rhesus monkey, Gorilla, Orangutan
  • Immunogen

    Synthetic peptide, corresponding to a region between amino acids 601-651 of Human BRD7 (NP_037395.2).

  • Positive control
    • Human Breast Carcinoma, Non-Small Cell Lung Cancer and Prostate Carcinoma tissues

Properties

Applications

Our Abpromise guarantee covers the use of ab114061 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/100 - 1/500. Epitope exposure is recommended. Epitope exposure with citrate buffer will enhance staining.

Target

  • Function
    Acts both as coactivator and as corepressor. May play a role in chromatin remodeling. Activator of the Wnt signaling pathway in a DVL1-dependent manner by negatively regulating the GSK3B phosphotransferase activity. Induces dephosphorylation of GSK3B at 'Tyr-216'. Down-regulates TRIM24-mediated activation of transcriptional activation by AR (By similarity). Transcriptional corepressor that down-regulates the expression of target genes. Binds to target promoters, leading to increased histone H3 acetylation at 'Lys-9' (H3K9ac). Binds to the ESR1 promoter. Recruits BRCA1 and POU2F1 to the ESR1 promoter. Coactivator for TP53-mediated activation of transcription of a set of target genes. Required for TP53-mediated cell-cycle arrest in response to oncogene activation. Promotes acetylation of TP53 at 'Lys-382', and thereby promotes efficient recruitment of TP53 to target promoters. Inhibits cell cycle progression from G1 to S phase.
  • Sequence similarities
    Contains 1 bromo domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt
  • Database links
  • Alternative names
    • 75 kDa bromodomain protein antibody
    • BP75 antibody
    • BRD 7 antibody
    • BRD7 antibody
    • BRD7_HUMAN antibody
    • Bromodomain containing 7 antibody
    • bromodomain containing protein 7 antibody
    • Bromodomain-containing protein 7 antibody
    • CELTIX 1 antibody
    • CELTIX1 antibody
    • NAG4 antibody
    • Protein CELTIX-1 antibody
    see all

Images

  • ab114061, at 1/250 dilution, staining BRD7 in formalin-fixed, paraffin-embedded Human Prostate carcinoma by Immunohistochemistry with DAB staining.

References

ab114061 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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