Overview

  • Product nameAnti-BRD8 antibody
    See all BRD8 primary antibodies
  • Description
    Rabbit polyclonal to BRD8
  • Tested applicationsSuitable for: IHC-Pmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Rat, Rabbit, Horse, Guinea pig, Dog, Pig, Rhesus monkey, Gorilla, Opossum, Chinese Hamster, Elephant
  • Immunogen

    Synthetic peptide corresponding to a region between residuse 200 and 250 of human BRD8 (Q969M9).

  • Positive control
    • Human prostate adenocarcinoma tissue.

Properties

Applications

Our Abpromise guarantee covers the use of ab84100 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P
  • Application notesIHC-P: 1/100 - 1/500. Epitope exposure with citrate buffer will enhance staining.


    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • RelevanceBRD8 may act as a coactivator during transcriptional activation by hormone-activated nuclear receptors (NR). Isoform 2 stimulates transcriptional activation by AR/DHTR, ESR1/NR3A1, RXRA/NR2B1 and THRB/ERBA2. At least isoform 1 and isoform 2 are components of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histone H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. It interacts with MYC and adenovirus E1A protein.
    • Cellular localizationNuclear
    • Database links
    • Alternative names
      • Bromodomain containing 8 antibody
      • p120 antibody
      • Skeletal muscle abundant protein antibody
      • Skeletal muscle abundant protein 2 antibody
      • SMAP antibody
      • SMAP2 antibody
      • Thyroid hormone receptor coactivating protein 120kDa antibody
      • Thyroid hormone receptor coactivating protein antibody
      see all

    Anti-BRD8 antibody images

    • ab84100 at 1/100 dilution staining BRD8 in human prostate adenocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.
    • ab84100 at 1/100 dilution staining BRD8 in human prostate adenocarcinoma by Immunohistochemistry, Formalin-fixed, Paraffin-embedded tissue. Detection: DAB staining.

    References for Anti-BRD8 antibody (ab84100)

    ab84100 has not yet been referenced specifically in any publications.

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"