Overview

  • Product nameBrilliant Blue G
  • Description
    Potent, noncompetitive P2X7 antagonist
  • Alternative names
    • Acid blue 90
    • Coomassie® Brilliant Blue G
  • Biological descriptionPotent, non-competitive antagonist of rat and human P2X7 receptors (IC50 values are 10 and 200 nM, respectively). Displays >1000-fold selectivity over P2X4. IC50 values for inhibition of the other P2X receptors range from 2 to >30 µM. Rat and human P2X4 receptors show IC50 values of >10 and 3.2 µM, respectively.

Properties

  • Chemical nameN-[4-[[4-[(4-Ethoxyphenyl)amino]phenyl][4-[ethyl[(3-sulfophenyl)methyl]amino]-2-methylphenyl]methylene]-3-methyl-2,5-cyclohexadien-1-ylidene]-N-ethyl-3-sulfobenzenemethanaminium , inner salt, sodium salt
  • Molecular weight854.02
  • Chemical structureChemical Structure
  • Molecular formulaC47H48N3NaO7S2
  • CAS Number6104-58-1
  • PubChem identifier61363
  • Storage instructionsStore at Room Temperature. The product can be stored for up to 12 months.
  • Solubility overviewSoluble in water to 50 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILESCC/[N+](Cc1cccc(c1)S([O-])(=O)=O)=C2/C=C/C(C(C)=C2)=C(/c4ccc(Nc3ccc(OCC)cc3)cc4)c5ccc(cc5C)N(Cc6cccc(c6)S(=O)(=O)O[Na])CC
  • Source

    Synthetic

  • Research areas

    References for Brilliant Blue G (ab120389)

    This product has been referenced in:
    • Ryu JK & McLarnon JG Block of purinergic P2X(7) receptor is neuroprotective in an animal model of Alzheimer's disease. Neuroreport 19:1715-9 (2008). Read more (PubMed: 18852683) »
    • Michel AD  et al. Direct labelling of the human P2X7 receptor and identification of positive and negative cooperativity of binding. Br J Pharmacol 151:103-14 (2007). Read more (PubMed: 17339830) »
    • Jiang LH  et al. Brilliant blue G selectively blocks ATP-gated rat P2X(7) receptors. Mol Pharmacol 58:82-8 (2000). Read more (PubMed: 10860929) »

    See 0 Publications for this product

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    Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"