Overview

  • Product name
    Anti-BRIT1 antibody [AB11]
    See all BRIT1 primary antibodies
  • Description
    Mouse monoclonal [AB11] to BRIT1
  • Host species
    Mouse
  • Tested applications
    Suitable for: ICC/IF, IP, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Other Immunogen Type corresponding to Human BRIT1. Recombinant BRIT1 polypeptides
    Database link: Q8NEM0

  • Positive control
    • HEK293 cell lysate

Properties

Applications

Our Abpromise guarantee covers the use of ab176524 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ICC/IF 1/50 - 1/200.
IP Use at an assay dependent concentration.
WB 1/1000.

Target

  • Function
    Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
  • Tissue specificity
    Expressed in fetal brain, liver and kidney.
  • Involvement in disease
    Defects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:251200]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.
  • Sequence similarities
    Contains 3 BRCT domains.
  • Cellular localization
    Cytoplasm > cytoskeleton > centrosome.
  • Information by UniProt
  • Database links
  • Alternative names
    • BRCT repeat inhibitor of TERT expression 1 antibody
    • BRIT 1 antibody
    • FLJ12847 antibody
    • Hypothetical protein FLJ12847 antibody
    • MCPH 1 antibody
    • MCPH1 antibody
    • MCPH1_HUMAN antibody
    • MCT antibody
    • Microcephalin 1 antibody
    • Microcephalin antibody
    • Microcephaly primary autosomal recessive 1 antibody
    see all

Images

  • All lanes : Anti-BRIT1 antibody [AB11] (ab176524) at 1/1000 dilution

    Lane 1 : No lysate
    Lane 2 : HEK293 cell lysate

    Developed using the ECL technique.
  • Immunocytochemical analysis of COS cells expressing GFP microcephalin  labeling BRIT1 with ab176524 at 1/50 dilution (middle panel) . Left panel BRIT1+GFP,  right panel merged image.

References

ab176524 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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