Overview

  • Product nameAnti-BRIT1 antibody
    See all BRIT1 primary antibodies
  • Description
    Mouse monoclonal to BRIT1
  • Tested applicationsSuitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment: ATSSCVTSAP EEALRCCRQA GKEDACPEGN GFSYTIEDPA LPKGHDDDLT PLEGSLEEMK EAVGLKSTQN KGTTSKISNS SEGEAQSEH, corresponding to amino acids 399-488 of Human BRIT1

Properties

Applications

Our Abpromise guarantee covers the use of ab57751 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB
  • Application notesWB: Use at a concentration of 1-5 µg/ml.

    This antibody has only been tested in WB against the recombinant fragment used as immunogen. We have no data on the detection of endogenous protein.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionImplicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.
    • Tissue specificityExpressed in fetal brain, liver and kidney.
    • Involvement in diseaseDefects in MCPH1 are the cause of microcephaly primary type 1 (MCPH1) [MIM:251200]; also known as true microcephaly or microcephaly vera. Microcephaly is defined as a head circumference more than 3 standard deviations below the age-related mean. Brain weight is markedly reduced and the cerebral cortex is disproportionately small. Despite this marked reduction in size, the gyral pattern is relatively well preserved, with no major abnormality in cortical architecture. Primary microcephaly is further defined by the absence of other syndromic features or significant neurological deficits. This entity is inherited as autosomal recessive trait.
    • Sequence similaritiesContains 3 BRCT domains.
    • Cellular localizationCytoplasm > cytoskeleton > centrosome.
    • Information by UniProt
    • Database links
    • Alternative names
      • BRCT repeat inhibitor of TERT expression 1 antibody
      • BRIT 1 antibody
      • FLJ12847 antibody
      • Hypothetical protein FLJ12847 antibody
      • MCPH 1 antibody
      • MCPH1 antibody
      • MCPH1_HUMAN antibody
      • MCT antibody
      • Microcephalin 1 antibody
      • Microcephalin antibody
      • Microcephaly primary autosomal recessive 1 antibody
      see all

    Anti-BRIT1 antibody images

    • Western blot against tagged recombinant protein immunogen using ab57751 BRIT1 antibody at 1ug/ml. Predicted band size of immunogen is 36 kDa

    References for Anti-BRIT1 antibody (ab57751)

    ab57751 has not yet been referenced specifically in any publications.

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