Biological descriptionSelective 5-HT1D antagonist. 60-fold higher affinity for 5-HT1D (pKi = 7.9) over 5-HT1B receptors. Brain penetrant.
Chemical name4-(3-Chlorophenyl)-α-(diphenylmethyl)-1-piperazineethanol hydrochloride
Storage instructionsStore at +4°C. Store under desiccating conditions. The product can be stored for up to 12 months.
Solubility overviewSoluble in DMSO to 10 mM and in ethanol to 50 mM
Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.
References for BRL 15572 monohydrochloride (ab120517)
This product has been referenced in:
Granados-Soto V et al. The role of peripheral 5-HT1A, 5-HT1B, 5-HT1D, 5-HT1E and 5-HT1F serotonergic receptors in the reduction of nociception in rats. Neuroscience165:561-8 (2010).
Read more (PubMed: 19837141) »
Price GW et al. SB-216641 and BRL-15572--compounds to pharmacologically discriminate h5-HT1B and h5-HT1D receptors. Naunyn Schmiedebergs Arch Pharmacol356:312-20 (1997).
Read more (PubMed: 9303567) »
Schlicker E et al. Effects of selective h5-HT1B (SB-216641) and h5-HT1D (BRL-15572) receptor ligands on guinea-pig and human 5-HT auto- and heteroreceptors. Naunyn Schmiedebergs Arch Pharmacol356:321-7 (1997).
Read more (PubMed: 9303568) »