Overview

  • Product nameAnti-BRRN1 antibody - Carboxyterminal end
    See all BRRN1 primary antibodies
  • Description
    Goat polyclonal to BRRN1 - Carboxyterminal end
  • Tested applicationsSuitable for: WB, ELISAmore details
  • Species reactivity
    Reacts with: Human
    Predicted to work with: Mouse
  • Immunogen

    Synthetic peptide:

    C-TEDLSDVLVRQGD

    , corresponding to C terminal amino acids 729-741 of Human BRRN1

  • Positive control
    • K562 cell lysate.

Properties

Associated products

Applications

Our Abpromise guarantee covers the use of ab62815 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 0.01 - 0.03 µg/ml. Detects a band of approximately 110 kDa (predicted molecular weight: 82 kDa).
ELISA 1/128000.

Target

  • FunctionRegulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases.
  • Tissue specificityWidely expressed at low level. Expressed in proliferating cells.
  • Sequence similaritiesBelongs to the CND2 (condensin subunit 2) family.
  • Post-translational
    modifications
    Phosphorylated by CDK1. Its phosphorylation, as well as that of NCAPD2 and NCAPG subunits, activates the condensin complex and is required for chromosome condensation.
  • Cellular localizationNucleus. Cytoplasm. Chromosome. In interphase cells, the majority of the condensin complex is found in the cytoplasm, while a minority of the complex is associated with chromatin. A subpopulation of the complex however remains associated with chromosome foci in interphase cells. During mitosis, most of the condensin complex is associated with the chromatin. At the onset of prophase, the regulatory subunits of the complex are phosphorylated by CDK1, leading to condensin's association with chromosome arms and to chromosome condensation. Dissociation from chromosomes is observed in late telophase.
  • Information by UniProt
  • Database links
  • Alternative names
    • Barren Drosophila Homolog of 1 antibody
    • Barren homolog protein 1 antibody
    • BRRN antibody
    • BRRN1 antibody
    • CAP H antibody
    • CAPH antibody
    • Chromosome associated protein H antibody
    • Chromosome-associated protein H antibody
    • CND2_HUMAN antibody
    • Condensin complex subunit 2 antibody
    • Condensin subunit 2 antibody
    • Condensin-2 complex subunit H2 antibody
    • Condesin antibody
    • HCAP H antibody
    • hCAP-H antibody
    • KIAA0074 antibody
    • mCAP H antibody
    • MGC4616 antibody
    • Ncaph antibody
    • Non SMC condensin I complex subunit H antibody
    • Non-SMC condensin I complex subunit H antibody
    • XCAP H homolog antibody
    • XCAP-H homolog antibody
    see all

Anti-BRRN1 antibody - Carboxyterminal end images

References for Anti-BRRN1 antibody - Carboxyterminal end (ab62815)

This product has been referenced in:
  • Pan X  et al. YY1 controls Ig? repertoire and B-cell development, and localizes with condensin on the Ig? locus. EMBO J 32:1168-82 (2013). Read more (PubMed: 23531880) »

See 1 Publication for this product

Product Wall

There are currently no Abreviews or Questions for ab62815.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"