Overview

  • Product nameAnti-BSND antibody
    See all BSND primary antibodies
  • Description
    Mouse polyclonal to BSND
  • Tested applicationsSuitable for: WB, IHC-Pmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length protein, corresponding to amino acids 1-320 of Human BSND (NP_476517.1)

  • Positive control
    • 293 cell lysate Transfected 293T cell lysate Human kidney tissue

Properties

Applications

Our Abpromise guarantee covers the use of ab88518 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB Use a concentration of 1 µg/ml. Predicted molecular weight: 35 kDa.
IHC-P Use a concentration of 3 µg/ml.

Target

  • FunctionFunctions as a beta-subunit for CLCNKA and CLCNKB chloride channels. In the kidney CLCNK/BSND heteromers mediate chloride reabsorption by facilitating its basolateral efflux. In the stria, CLCNK/BSND channels drive potassium secretion by recycling chloride for the basolateral SLC12A2 cotransporter.
  • Tissue specificityExpressed primarily in kidney. Expressed in specific nephron segments and in the stria vascularis of the inner ear.
  • Involvement in diseaseBartter syndrome 4A
  • Cellular localizationCell membrane. Cytoplasm. A significant amount also observed intracellularly. Staining in membranes of the renal tubule and of potassium-secreting epithelia of the inner ear is basolateral.
  • Information by UniProt
  • Database links
  • Alternative names
    • BART antibody
    • Bartter syndrome infantile with sensorineural deafness antibody
    • Bartter syndrome, infantile, with sensorineural deafness (Barttin) antibody
    • Barttin antibody
    • Bsnd antibody
    • BSND_HUMAN antibody
    • deafness, autosomal recessive 73 antibody
    • DFNB 73 antibody
    • DFNB73 antibody
    see all

Anti-BSND antibody images

  • Anti-BSND antibody (ab88518) at 1 µg/ml + 293 cell lysate at 50 µg

    Secondary
    Goat anti-mouse IgG at 1/5000 dilution

    Predicted band size : 35 kDa
  • All lanes : Anti-BSND antibody (ab88518) at 1 µg/ml

    Lane 1 : BSND transfected 293T cell lysate
    Lane 2 : Untransfected 293T cell lysate

    Lysates/proteins at 25 µg per lane.

    Secondary
    Goat anti-mouse IgG at 1/5000 dilution

    Predicted band size : 35 kDa
    Observed band size : 35 kDa
  • Immunoperoxidase staining of human kidney tissue labelled with ab88518 at 3 µg/ml

References for Anti-BSND antibody (ab88518)

ab88518 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"