Overview

  • Product nameAnti-BST2 antibody
    See all BST2 primary antibodies
  • Description
    Rabbit polyclonal to BST2
  • Tested applicationsSuitable for: Dot blot, ELISA, WBmore details
  • Species reactivity
    Reacts with: Rat, Human
  • Immunogen

    Synthetic peptide (Human) (Position 121-140 on human BST2).

  • Positive control
    • Rat neonatal brain.

Properties

Applications

Our Abpromise guarantee covers the use of ab14694 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Dot blot 1/2000.
ELISA 1/2000.
WB 1/500 - 1/1000. Detects a band of approximately 20 kDa (predicted molecular weight: 20 kDa).

Target

  • FunctionMay be involved in the sorting of secreted proteins (By similarity). May be involved in pre-B-cell growth. Antiretroviral defense protein, that blocks release of retrovirus from the cell surface. Depleted unpon HIV-1 infection by viral VPU protein through 20S proteasome degradation. Depleted upon infection by human Kaposi's sarcoma-associated herpesvirus (KSHV) through ubiquitination and subsequent degradation. May play a role in B-cell activation in rheumatoid arthritis.
  • Tissue specificityPredominantly expressed in liver, lung, heart and placenta. Lower levels in pancreas, kidney, skeletal muscle and brain. Overexpressed in multiple myeloma cells. Highly expressed during B-cell development, from pro-B precursors to plasma cells. Highly expressed on T-cells, monocytes, NK cells and dendritic cells (at protein level).
  • Sequence similaritiesBelongs to the tetherin family.
  • DomainThe extracellular coiled coil domain is important for virus retention at the cell surface and prevention of virus spreading.
  • Post-translational
    modifications
    Monoubiquitinated by KSHV E3 ubiquitin-protein ligase K5, leading to its targeting to late endosomes and degradation.
  • Cellular localizationGolgi apparatus > trans-Golgi network. Cell membrane. Cell membrane. Late endosome. Targeted to late endosomes upon KSHV infection and subsequent ubiquitination. Targeted to the trans-Golgi network by viral VPU protein.
  • Information by UniProt
  • Database links
  • Alternative names
    • Bone marrow stromal antigen 2 antibody
    • Bone marrow stromal cell antigen 2 antibody
    • Bone marrow stromal cell antigen antibody
    • BST 2 antibody
    • BST-2 antibody
    • BST2 antibody
    • BST2_HUMAN antibody
    • CD 317 antibody
    • CD317 antibody
    • CD317 antigen antibody
    • HM1.24 antigen antibody
    • NPC A 7 antibody
    • Tetherin antibody
    see all

References for Anti-BST2 antibody (ab14694)

This product has been referenced in:
  • Rollason R  et al. A CD317/tetherin-RICH2 complex plays a critical role in the organization of the subapical actin cytoskeleton in polarized epithelial cells. J Cell Biol 184:721-36 (2009). Read more (PubMed: 19273615) »
  • Rollason R  et al. Clathrin-mediated endocytosis of a lipid-raft-associated protein is mediated through a dual tyrosine motif. J Cell Sci 120:3850-8 (2007). Read more (PubMed: 17940069) »

See all 2 Publications for this product

Product Wall

Thank you for your enquiry. I can confirm that this product, ab14694 recognizes both the precursor protein of around 21kDa and the post translationally modified form of higher molecular weights. I hope this information will be helpful. If there...

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Thank you for your enquiry. Ab14694 cross-reacts with human and rat BST2, and cross-reacts weakly with mouse. Rat neonatal brain or human recombinant protein are recommended as positive controls. If you have any additional questions, please contact...

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Thank you for your enquiry. To answer your question. Yes, the antibody does contain 0.001% sodium azide with other preservatives. The antibody stabilization buffer also contains stabilizing proteins beside IgGs. I hope this information helps. P...

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"