Overview

  • Product name
    BTS
  • Description
    Selective inhibitor of Ca2+-stimulated myosin S1 ATPase
  • Alternative names
    • 4-Methyl-N-(phenylmethyl)benzenesulfonamide
    • Battenin
    • CLN3
    • N-Benzyl-4-methylbenzenesulfonamide
    • N-Benzyl-p-toluenesulphonamide
    • NSC 37123
    see all
  • Biological description

    Selective inhibitor of Ca2+-stimulated myosin S1 ATPase (IC50 = ~5 µM). Reversibly blocks the gliding motility and weakens myosin’s interaction with F-actin. Much less effective in suppressing contraction in rat myocardial or rabbit slow twitch muscle and has no effect on platelet myosin II.

  • Purity
    > 95%

Properties

  • Chemical name
    N-Benzyl-p-toluenesulphonamide
  • Molecular weight
    261.30
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C14H15NO2S
  • CAS Number
    1576-37-0
  • Storage instructions
    Store at -20°C. Store under desiccating conditions. The product can be stored for up to 12 months.
  • Solubility overview
    Soluble in DMSO
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • Source

    Synthetic

References

This product has been referenced in:
  • Dentel JN  et al. Inhibition of cross-bridge formation has no effect on contraction-associated phosphorylation of p38 MAPK in mouse skeletal muscle. Am J Physiol Cell Physiol 288:C824-30 (2005). Read more (PubMed: 15574487) »
  • Ramachandran I  et al. Skeletal muscle myosin cross-bridge cycling is necessary for myofibrillogenesis. Cell Motil Cytoskeleton 55:61-72 (2003). Read more (PubMed: 12673599) »
  • Shaw MA  et al. Mechanism of inhibition of skeletal muscle actomyosin by N-benzyl-p-toluenesulfonamide. Biochemistry 42:6128-35 (2003). Read more (PubMed: 12755615) »
  • Cheung A  et al. A small-molecule inhibitor of skeletal muscle myosin II. Nat Cell Biol 4:83-8 (2002). Read more (PubMed: 11744924) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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