Anti-Butyrylcholinesterase antibody [3E8] (ab17246)

Overview

  • Product nameAnti-Butyrylcholinesterase antibody [3E8]
    See all Butyrylcholinesterase primary antibodies
  • Description
    Mouse monoclonal [3E8] to Butyrylcholinesterase
  • SpecificityNo reaction is seen with acetylcholinesterase from human nervous tissue and erythrocytes.
  • Tested applicationsSuitable for: ELISAmore details
    Unsuitable for: WB
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native protein (purified) (Human).

Properties

Applications

Our Abpromise guarantee covers the use of ab17246 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA 1/8000.
  • Application notesIs unsuitable for WB.
  • Target

    • FunctionEsterase with broad substrate specificity. Contributes to the inactivation of the neurotransmitter acetylcholine. Can degrade neurotoxic organophosphate esters.
    • Tissue specificityDetected in blood plasma (at protein level). Present in most cells except erythrocytes.
    • Involvement in diseaseDefects in BCHE are the cause of butyrylcholinesterase deficiency (BChE deficiency) [MIM:177400]. BChE deficiency is a metabolic disorder characterized by prolonged apnoea after the use of certain anesthetic drugs, including the muscle relaxants succinylcholine or mivacurium and other ester local anesthetics. The duration of the prolonged apnoea varies significantly depending on the extent of the enzyme deficiency. BChE deficiency is a multifactorial disorder. The hereditary condition is transmitted as an autosomal recessive trait.
    • Sequence similaritiesBelongs to the type-B carboxylesterase/lipase family.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • Acylcholine acylhydrolase antibody
      • BCHE antibody
      • Butyrylcholine esterase antibody
      • CHE1 antibody
      • CHE2 antibody
      • CHLE_HUMAN antibody
      • Choline esterase II antibody
      • Cholinesterase (serum) 2 antibody
      • Cholinesterase 1 antibody
      • Cholinesterase antibody
      • E1 antibody
      • Pseudocholinesterase antibody
      • Pseudocholinesterase E1 antibody
      see all

    References for Anti-Butyrylcholinesterase antibody [3E8] (ab17246)

    ab17246 has not yet been referenced specifically in any publications.

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