Overview

  • Product name
  • Description
    Rabbit polyclonal to BVES
  • Tested applications
    Suitable for: IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Synthetic peptide within Human BVES aa 312-342 (C terminal) conjugated to Keyhole Limpet Haemocyanin (KLH). The exact sequence is proprietary.
    Database link: Q8NE79

  • Positive control
    • 293 cell lysate, Human heart tissue.

Properties

  • Form
    Liquid
  • Storage instructions
    Shipped at 4°C. Store at +4°C short term (1-2 weeks). Upon delivery aliquot. Store at -20°C long term. Avoid freeze / thaw cycle.
  • Storage buffer
    Preservative: 0.09% Sodium azide
    Constituent: 99% PBS
  • Concentration information loading...
  • Purity
    Protein A purified
  • Clonality
    Polyclonal
  • Isotype
    IgG
  • Research areas

Applications

Our Abpromise guarantee covers the use of ab171550 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
IHC-P 1/10 - 1/50. Perform heat mediated antigen retrieval with citrate buffer pH 6 before commencing with IHC staining protocol.
WB 1/100 - 1/500. Predicted molecular weight: 41 kDa.

Target

  • Function
    Cell adhesion molecule involved in the establishment and/or maintenance of cell integrity. Involved in the formation and regulation of the tight junction (TJ) paracellular permeability barrier in epithelial cells. Plays a role in VAMP3-mediated vesicular transport and recycling of different receptor molecules through its interaction with VAMP3. Plays a role in the regulation of cell shape and movement by modulating the Rho-family GTPase activity through its interaction with ARHGEF25/GEFT. Induces primordial adhesive contact and aggregation of epithelial cells in a Ca(2+)-independent manner. Also involved in striated muscle regeneration and repair and in the regulation of cell spreading.
  • Tissue specificity
    Expressed in epithelial cells (at protein level). Expressed in fetal and adult heart and skeletal muscle.
  • Sequence similarities
    Belongs to the popeye family.
  • Cellular localization
    Lateral cell membrane. Cell junction > tight junction. Membrane. Colocalizes with VAMP3 at the cell-cell contact in cardiac and skeletal muscle (By similarity). Its movement from the cytoplasm to membrane is an early event occurring concurrently with cell-cell contact. Colocalizes in epithelial cells with OCLN and TJP1 in an apical-lateral position within the z axis. Detected at cell-cell contact but never observed at the free surface of epithelial cells.
  • Information by UniProt
  • Database links
  • Alternative names
    • Blood vessel epicardial substance antibody
    • Bves antibody
    • hBVES antibody
    • MGC42413 antibody
    • POP 1 antibody
    • POP1 antibody
    • POPD1_HUMAN antibody
    • POPDC 1 antibody
    • POPDC1 antibody
    • Popeye domain containing 1 antibody
    • Popeye domain containing protein 1 antibody
    • Popeye domain-containing protein 1 antibody
    • Popeye protein 1 antibody
    see all

Images

  • Anti-BVES antibody (ab171550) at 1/100 dilution + 293 cell lysate at 35 µg

    Predicted band size : 41 kDa
  • Immunohistochemical analysis of paraffin-embedded Human heart tissue, labeling BVES with ab171550 at 1/10 dilution. IHC was followed by peroxidase treatment.

References

ab171550 has not yet been referenced specifically in any publications.

Customer reviews and Q&As

There are currently no Customer reviews or Questions for ab171550.
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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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