Overview

  • Product name
    BVT 948
  • Description
    Non-competitive, irreversible protein tyrosine phosphatase (PTP) inhibitor
  • Biological description
    Non-competitive, irreversible protein tyrosine phosphatase (PTP) inhibitor (IC50 values are 0.9 (PTP1B), 1.7 (TCPTP), 0.09 (SHP-2), 1.5 (LAR) and 0.7 (YopH) μM). Active in vivo and cell-permeable.
  • Purity
    > 99%

Properties

  • Chemical name
    4-Hydroxy-3,3-dimethyl-2H-benz[g]indole-2,5(3H)-dione
  • Molecular weight
    241.25
  • Chemical structure
    Chemical Structure
  • Molecular formula
    C14H11NO3
  • CAS Number
    39674-97-0
  • PubChem identifier
    6604934
  • Storage instructions
    Store at -20°C. It is important to note that this product is reported to be light sensitive. Store In the Dark. Store under desiccating conditions.
  • Solubility overview
    Soluble in DMSO to 50 mM and in ethanol to 20 mM
  • Handling

    Wherever possible, you should prepare and use solutions on the same day. However, if you need to make up stock solutions in advance, we recommend that you store the solution as aliquots in tightly sealed vials at -20°C. Generally, these will be useable for up to one month. Before use, and prior to opening the vial we recommend that you allow your product to equilibrate to room temperature for at least 1 hour.

    Need more advice on solubility, usage and handling? Please visit our frequently asked questions (FAQ) page for more details.

  • SMILES
    OC=2C(=O)c1ccccc1C3=NC(=O)C(C)(C)C=23
  • Source

    Synthetic

  • Research areas

References

This product has been referenced in:
  • Liljebris C  et al. Oxidation of protein tyrosine phosphatases as a pharmaceutical mechanism of action: a study using 4-hydroxy-3,3-dimethyl-2H-benzo[g]indole-2,5(3H)-dione. J Pharmacol Exp Ther 309:711-9 (2004). Read more (PubMed: 14747616) »

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE, NOT FOR USE IN HUMANS"

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