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Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - c Abl antibody (ab15130)
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Product Name
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c Abl antibody
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See all c Abl antibodies (21)...
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Product type
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Primary antibodies
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Description
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Rabbit polyclonal to c Abl
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Immunogen
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A synthetic peptide from the sequence adjacent to protein tyrosine kinase domain of human c-Abl.
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Reacts with
(species key)
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Hu, Ms
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Tested applications
(see key)
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IHC-P, IP, WB
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Abreviews
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Application notes
(see key)
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Recommended dilutions
IHC-P: 1/50 for 10 min at RT. Boil tissue sections in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.
IP: Use at an assay dependent dilution.
WB: Use at an assay dependent dilution. Predicted molecular weight: 122.9 kDa.
Not tested in other applications.
Optimal dilutions/concentrations should be determined by the end user.
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Positive control
(see definition)
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Placenta.
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Cellular localization
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Cytoplasmic and Nuclear
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Research areas
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Cancer >> Oncoproteins/suppressors >> Oncoproteins >> Signal transducers
Chromatin and Nuclear Signaling >> Transcription >> Cancer susceptibility >> Proto-oncogenes
Signal Transduction >> Protein Phosphorylation >> Tyrosine Kinases >> Other
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Relevance
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The c Abl proto oncogene encodes a protein tyrosine kinase that is located in the cytoplasm and nucleus. In chronic myelogenous leukemia and in a subset of acute lymphoblastic leukemias, the c Abl proto oncogene undergoes a (9;22) chromosomal translocation producing a novel rearranged chromosome (the Philadelphia chromosome) As the result of the fusion of c Abl sequences from chromosome 9 to the Bcr gene on chromosome 22. The molecular consequence of this translocation is the generation of a chimeric Bcr/Abl mRNA encoding activated Abl protein tyrosine kinase.
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Database links
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The links below go to external sites and will open in a new browser window |
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Raised in
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Rabbit
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Clonality
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Polyclonal
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Isotype
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IgG
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Purity
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Immunogen affinity purified
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Storage buffer
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Preservative: 0.1% Sodium Azide
Constituents: 1% BSA, 10mM PBS, pH 7.4 Material safety datasheet (MSDS) for this product:
Sodium Azide MSDS
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Form
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Liquid
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Concentration
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0.200 mg/ml
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Storage instructions
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Store at +4°C.
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At Abcam, we have one centralized database to hold all of our product information, so that everything we know about this c Abl antibody is on this datasheet. But please do contact us if you would like any reassurance! |
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See below for c Abl antibody images, references, products related to ab15130 and other tools.
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c Abl antibody images:
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 Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections) - c Abl antibody (ab15130)
ab15130 staining c-Abl in human placenta by Immunohistochemistry (FFPE-sections)..
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Search PubMed (MEDLINE) for references to c Abl
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c Abl antibody - more information
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Customer reviews (feedback) regarding c Abl antibody |
Customer FAQs regarding c Abl antibody |
Protocols for c Abl antibody |
Price and availability of products related to c Abl antibody |
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c Abl antibody - related products:
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c Abl antibody - other tools:
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Contact Abcam with a Technical Enquiry about c Abl antibody |
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All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"
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