Anti-c-Jun antibody (ab428)

Overview

• Product nameAnti-c-Jun antibodySee all c-Jun primary antibodies ...
• Description
  Rabbit polyclonal to c-Jun
• SpecificityReacts with 32 kDa protein derived from avian and mammalian E.F. cells. Cross reacts with avian v-Jun protein.
• Tested applicationsWB, EMSA more details
• Species reactivity
  Reacts with: Chicken, all Mammals
  Predicted to work with: Bird
• Immunogen

  Fusion protein.

Properties

• FormLiquid
• Storage instructionsStore at +4°C short term (1-2 weeks). Aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.
• Storage bufferPreservative: None
  Constituents: Whole Serum
• PurityWhole antiserum
• Clonality Polyclonal
• IsotypeIgG
• Research Areas
  • Cancer
  • Oncoproteins/suppressors
  • Oncoproteins
  • Transcription factors

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Domain Families
  • HLH / Leucine Zipper
  • Leucine Zipper

  • Epigenetics and Nuclear Signaling
  • Transcription
  • Cancer susceptibility
  • Proto-oncogenes

  • Immunology
  • Innate Immunity
  • TLR Signaling

Applications

Target

• FunctionTranscription factor that recognizes and binds to the enhancer heptamer motif 5'-TGA[CG]TCA-3'. Promotes activity of NR5A1 when phosphorylated by HIPK3 leading to increased steroidogenic gene expression upon cAMP signaling pathway stimulation.
• Sequence similaritiesBelongs to the bZIP family. Jun subfamily.
  Contains 1 bZIP (basic-leucine zipper) domain.
• Post-translational
  modificationsPhosphorylated by CaMK4 and PRKDC; phosphorylation enhances the transcriptional activity. Phosphorylated by HIPK3. Phosphorylated by DYRK2 at Ser-243; this primes the protein for subsequent phosphorylation by GSK3B at Thr-239. Phosphorylated at Thr-239, Ser-243 and Ser-249 by GSK3B; phosphorylation reduces its ability to bind DNA. Phosphorylated by PAK2 at Thr-2, Thr-8, Thr-89, Thr-93 and Thr-286 thereby promoting JUN-mediated cell proliferation and transformation. Phosphorylated by PLK3 following hypoxia or UV irradiation, leading to increase DNA-binding activity.
  Acetylated at Lys-271 by EP300.
• Cellular localizationNucleus.

Target information above from: UniProt accession P05412 The UniProt Consortium
The Universal Protein Resource (UniProt) in 2010
Nucleic Acids Res. 38:D142-D148 (2010) .

Information by UniProt
• Database links
  • Entrez Gene: 424673 Chicken
  • SwissProt: P18870 Chicken

• Alternative names
  Activator Protein 1 antibodyAP 1 antibodyAP1 antibody

  cJun antibodyEnhancer Binding Protein AP1 antibodyJun Activation Domain Binding Protein antibodyJUN antibodyJun oncogene antibodyJUN protein antibodyJun proto oncogene antibodyJUN_HUMAN antibodyJUNC antibodyOncogene JUN antibodyp39 antibodyProto oncogene c jun antibodyProto oncogene cJun antibodyProto-oncogene c-jun antibodyTranscription Factor AP 1 antibodyTranscription factor AP-1 antibodyTranscription factor AP1 antibodyV jun avian sarcoma virus 17 oncogene homolog antibodyV jun sarcoma virus 17 oncogene homolog (avian) antibodyV jun sarcoma virus 17 oncogene homolog antibodyV-jun avian sarcoma virus 17 oncogene homolog antibodyvJun Avian Sarcoma Virus 17 Oncogene Homolog antibody

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