Transcriptional activator; DNA-binding protein that specifically recognize the sequence 5'-YAAC[GT]G-3'. Plays an important role in the control of proliferation and differentiation of hematopoietic progenitor cells.
Contains 3 HTH myb-type DNA-binding domains.
Comprised of 3 domains; an N-terminal DNA-binding domain, a centrally located transcriptional activation domain and a C-terminal domain involved in transcriptional repression.
Ubiquitinated; mediated by SIAH1 and leading to its subsequent proteasomal degradation. Phosphorylated by NLK on multiple sites, which induces proteasomal degradation.
Baron BW et al. GFI1B, EVI5, MYB-Additional genes that cooperate with the human BCL6 gene to promote the development of lymphomas. Blood Cells Mol DisN/A:N/A (2013).
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