• Product nameAnti-C Reactive Protein antibody [C4]
    See all C Reactive Protein primary antibodies
  • Description
    Mouse monoclonal [C4] to C Reactive Protein
  • SpecificityThis product recognizes only the pentameric C reactive protein. Does not react with Ca2+ depleted protein
  • Tested applicationsSuitable for: ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Full length native protein (purified) (Human).

  • General notes

    Concentration varies from lot to lot and can be provided on request.



Our Abpromise guarantee covers the use of ab10028 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
ELISA Use at an assay dependent concentration.


  • FunctionDisplays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
  • Tissue specificityFound in plasma.
  • Sequence similaritiesBelongs to the pentaxin family.
    Contains 1 pentaxin domain.
  • Cellular localizationSecreted.
  • Information by UniProt
  • Database links
  • Alternative names
    • Pentraxin 1, short antibody
    • C reactive protein antibody
    • C reactive protein pentraxin related antibody
    • C-reactive protein(1-205) antibody
    • CRP antibody
    • CRP_HUMAN antibody
    • MGC88244 antibody
    • Pentraxin 1 antibody
    • PTX 1 antibody
    • PTX1 antibody
    see all

Anti-C Reactive Protein antibody [C4] images

  • Sensitivity to EDTA. Serum samples with (dark blue) and w/o (light blue) Ca2+ ions were tested by two two-site combinations of anti-CRP MAbs. Ab10028 [C4] is sensitive to the conformational changes of CRP molecule and thus the assay gives no signal in the presence of EDTA. Sandwich immunoassay utilizing ab8277 [C2] and ab8278 [C6] recognizes the antigen with the same efficiency in the presence and in the absence of EDTA.

References for Anti-C Reactive Protein antibody [C4] (ab10028)

This product has been referenced in:
  • Trilok-Kumar G  et al. Effect of vitamin D supplementation of low birth weight term Indian infants from birth on cytokine production at 6 months. Eur J Clin Nutr 66:746-50 (2012). Read more (PubMed: 22510791) »

See 1 Publication for this product

Product Wall

I have confirmed with the lab and most of our C Reactive Protein antibodies, except C3 and C4, react with both monomer and pentamer form of CRP. (As our clones C3 and C4 do not recognize CRP in the absence of Ca2+ ions, we suggest that they could ...

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We have tested the antibody ab10028 in ELISA only and as it is does not recognize CRP in the absence of Ca2+ ions, so it could not recognize CRP monomer form.
We have not tested ab10028 in western blot so I am sorry we are unable to confirm its sp...

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Thank you for your patience. I am sorry that our system was down yesterday. Further to your enquiry; We have several antibodies that are suitable for sandwich ELISA as a pair. For example; C Reactive Protein antibody [C4] (ab10028) can be pai...

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