Overview

  • Product namec-Rel peptide

Description

  • NatureSynthetic

Specifications

Our Abpromise guarantee covers the use of ab7557 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • FormLiquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.01% Sodium Azide

General Info

  • Alternative names
    • Avian reticuloendotheliosis
    • C REL
    • C Rel protein
    • c Rel proto oncogene protein
    • Oncogene REL
    • Oncogene REL avian reticuloendotheliosis
    • Proto-oncogene c-Rel
    • REL
    • REL_HUMAN
    • v rel avian reticuloendotheliosis viral oncogene homolog
    • v rel reticuloendotheliosis viral oncogene homolog
    • V rel reticuloendotheliosis viral oncogene homolog (avian)
    see all
  • FunctionProto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
  • Sequence similaritiesContains 1 RHD (Rel-like) domain.
  • Cellular localizationNucleus.
  • Information by UniProt

References for c-Rel peptide (ab7557)

ab7557 has not yet been referenced specifically in any publications.

Product Wall

There are currently no Abreviews or Questions for ab7557.
Please use the links above to contact us or submit feedback about this product.

Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"