Overview

  • Product name
    c-Rel peptide

Description

  • Nature
    Synthetic

Specifications

Our Abpromise guarantee covers the use of ab7557 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

  • Applications

    Blocking

  • Form
    Liquid
  • Concentration information loading...

Preparation and Storage

  • Stability and Storage

    Shipped at 4°C. Upon delivery aliquot and store at -20°C or -80°C. Avoid repeated freeze / thaw cycles.

    Preservative: 0.01% Sodium Azide

General Info

  • Alternative names
    • Avian reticuloendotheliosis
    • C REL
    • C Rel protein
    • c Rel proto oncogene protein
    • Oncogene REL
    • Oncogene REL avian reticuloendotheliosis
    • Proto-oncogene c-Rel
    • REL
    • REL_HUMAN
    • v rel avian reticuloendotheliosis viral oncogene homolog
    • v rel reticuloendotheliosis viral oncogene homolog
    • V rel reticuloendotheliosis viral oncogene homolog (avian)
    see all
  • Function
    Proto-oncogene that may play a role in differentiation and lymphopoiesis. NF-kappa-B is a pleiotropic transcription factor which is present in almost all cell types and is involved in many biological processed such as inflammation, immunity, differentiation, cell growth, tumorigenesis and apoptosis. NF-kappa-B is a homo- or heterodimeric complex formed by the Rel-like domain-containing proteins RELA/p65, RELB, NFKB1/p105, NFKB1/p50, REL and NFKB2/p52. The dimers bind at kappa-B sites in the DNA of their target genes and the individual dimers have distinct preferences for different kappa-B sites that they can bind with distinguishable affinity and specificity. Different dimer combinations act as transcriptional activators or repressors, respectively. NF-kappa-B is controlled by various mechanisms of post-translational modification and subcellular compartmentalization as well as by interactions with other cofactors or corepressors. NF-kappa-B complexes are held in the cytoplasm in an inactive state complexed with members of the NF-kappa-B inhibitor (I-kappa-B) family. In a conventional activation pathway, I-kappa-B is phosphorylated by I-kappa-B kinases (IKKs) in response to different activators, subsequently degraded thus liberating the active NF-kappa-B complex which translocates to the nucleus. The NF-kappa-B heterodimer RELA/p65-c-Rel is a transcriptional activator.
  • Sequence similarities
    Contains 1 RHD (Rel-like) domain.
  • Cellular localization
    Nucleus.
  • Information by UniProt

References

ab7557 has not yet been referenced specifically in any publications.

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Please note: All products are "FOR RESEARCH USE ONLY AND ARE NOT INTENDED FOR DIAGNOSTIC OR THERAPEUTIC USE"

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