• Product name
    Anti-C1 Inactivator antibody
    See all C1 Inactivator primary antibodies
  • Description
    Mouse monoclonal to C1 Inactivator
  • Tested applications
    Suitable for: IHC-Fr, IHC-P, WBmore details
  • Species reactivity
    Reacts with: Human, Recombinant fragment
  • Immunogen

    Recombinant full length protein, corresponding to amino acids 1-501 of Human C1 Inactivator



Our Abpromise guarantee covers the use of ab54898 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
  • Application notes
    IHC-P: Use at a concentration of 1 µg/ml.
    IHC-Fr: Use at an assay dependent dilution (PMID 19607829).
    WB: Use at a concentration of 1 - 5 µg/ml.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • Function
      Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
    • Involvement in disease
      Defects in SERPING1 are the cause of hereditary angioedema (HAE) [MIM:106100]; also called hereditary angioneurotic edema (HANE). HAE is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In HAE type 1, representing 85% of patients, serum levels of C1 esterase inhibitor are less than 35% of normal. In HAE type 2, the levels are normal or elevated, but the protein is non-functional.
    • Sequence similarities
      Belongs to the serpin family.
    • Post-translational
      Highly glycosylated (49%) with N- and O-glycosylation.
      Can be proteolytically cleaved by E.coli stcE.
    • Cellular localization
    • Information by UniProt
    • Database links
    • Alternative names
      • C1 esterase inhibitor antibody
      • C1 Inh antibody
      • C1 inhibiting factor antibody
      • C1 inhibitor antibody
      • C1-inhibiting factor antibody
      • C1IN antibody
      • C1Inh antibody
      • C1NH antibody
      • complement component 1 inhibitor antibody
      • esterase inhibitor antibody
      • HAE1 antibody
      • HAE2 antibody
      • IC1_HUMAN antibody
      • Plasma protease C1 inhibitor antibody
      • Serine (or cysteine) proteinase inhibitor clade G member 1 antibody
      • serine/cysteine proteinase inhibitor clade G member 1 antibody
      • Serpin G1 antibody
      • serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 antibody
      • SERPING1 antibody
      see all

    Anti-C1 Inactivator antibody images

    • C1 Inactivator antibody (ab54898) used in immunohistochemistry at 1ug/ml on formalin fixed and paraffin embedded human kidney.
    • Western blot against tagged recombinant protein immunogen using ab54898 C1 Inactivator antibody at 1ug/ml. Predicted band size of immunogen is 81 kDa

    References for Anti-C1 Inactivator antibody (ab54898)

    This product has been referenced in:
    • Janssen SF  et al. Gene expression and functional annotation of the human ciliary body epithelia. PLoS One 7:e44973 (2012). IHC-FoFr ; Human . Read more (PubMed: 23028713) »
    • Mullins RF  et al. Localization of complement 1 inhibitor (C1INH/SERPING1) in human eyes with age-related macular degeneration. Exp Eye Res 89:767-73 (2009). IHC-Fr ; Human . Read more (PubMed: 19607829) »

    See all 2 Publications for this product

    Product Wall

    Thank you for your interest in this C1INH/SERPING1 antibody. That blot on the datasheet is of a tagged recombinant protein, and the GST tag itself is 26 kDa.

    The predicted size of the precursor of the endogenous protein, before any post-transl...

    Read More

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