• Product name
    Anti-C1 Inactivator antibody
    See all C1 Inactivator primary antibodies
  • Description
    Rabbit polyclonal to C1 Inactivator
  • Tested applications
    Suitable for: WBmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Recombinant fragment, corresponding to a region within amino acids 77-390 of Human C1 Inactivator (NP_000053).

  • Positive control
    • 293T, A431, H1299, HeLa S3, HepG2, MOLT4 and Raji cell lysates.



Our Abpromise guarantee covers the use of ab97348 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
WB 1/500 - 1/3000. Predicted molecular weight: 55 kDa.


  • Function
    Activation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
  • Involvement in disease
    Defects in SERPING1 are the cause of hereditary angioedema (HAE) [MIM:106100]; also called hereditary angioneurotic edema (HANE). HAE is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In HAE type 1, representing 85% of patients, serum levels of C1 esterase inhibitor are less than 35% of normal. In HAE type 2, the levels are normal or elevated, but the protein is non-functional.
  • Sequence similarities
    Belongs to the serpin family.
  • Post-translational
    Highly glycosylated (49%) with N- and O-glycosylation.
    Can be proteolytically cleaved by E.coli stcE.
  • Cellular localization
  • Information by UniProt
  • Database links
  • Alternative names
    • C1 esterase inhibitor antibody
    • C1 Inh antibody
    • C1 inhibiting factor antibody
    • C1 inhibitor antibody
    • C1-inhibiting factor antibody
    • C1IN antibody
    • C1Inh antibody
    • C1NH antibody
    • complement component 1 inhibitor antibody
    • esterase inhibitor antibody
    • HAE1 antibody
    • HAE2 antibody
    • IC1_HUMAN antibody
    • Plasma protease C1 inhibitor antibody
    • Serine (or cysteine) proteinase inhibitor clade G member 1 antibody
    • serine/cysteine proteinase inhibitor clade G member 1 antibody
    • Serpin G1 antibody
    • serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 antibody
    • SERPING1 antibody
    see all

Anti-C1 Inactivator antibody images

  • All lanes : Anti-C1 Inactivator antibody (ab97348) at 1/1000 dilution

    Lane 1 : 293T whole cell lysate
    Lane 2 : HeLa S3 whole cell lysate

    Lysates/proteins at 30 µg per lane.

    Predicted band size : 55 kDa

References for Anti-C1 Inactivator antibody (ab97348)

This product has been referenced in:
  • Hansen HG  et al. Versatile microscale screening platform for improving recombinant protein productivity in Chinese hamster ovary cells. Sci Rep 5:18016 (2015). WB . Read more (PubMed: 26657798) »

See 1 Publication for this product

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