Anti-C1 Inactivator antibody [KT28] (ab53365)

Overview

  • Product nameAnti-C1 Inactivator antibody [KT28]
    See all C1 Inactivator primary antibodies
  • Description
    Mouse monoclonal [KT28] to C1 Inactivator
  • Tested applicationsSuitable for: Indirect ELISAmore details
  • Species reactivity
    Reacts with: Human
  • Immunogen

    Purified C1 inactivator from human blood

Properties

Applications

Our Abpromise guarantee covers the use of ab53365 in the following tested applications.

The application notes include recommended starting dilutions; optimal dilutions/concentrations should be determined by the end user.

Application Abreviews Notes
Indirect ELISA
  • Application notesI-ELISA: Use at a concentration of 5 µg/ml as primary antibody.

    Not yet tested in other applications.
    Optimal dilutions/concentrations should be determined by the end user.
  • Target

    • FunctionActivation of the C1 complex is under control of the C1-inhibitor. It forms a proteolytically inactive stoichiometric complex with the C1r or C1s proteases. May play a potentially crucial role in regulating important physiological pathways including complement activation, blood coagulation, fibrinolysis and the generation of kinins. Very efficient inhibitor of FXIIa. Inhibits chymotrypsin and kallikrein.
    • Involvement in diseaseDefects in SERPING1 are the cause of hereditary angioedema (HAE) [MIM:106100]; also called hereditary angioneurotic edema (HANE). HAE is an autosomal dominant disorder characterized by episodic local subcutaneous edema and submucosal edema involving the upper respiratory and gastrointestinal tracts. HAE due to C1 esterase inhibitor deficiency is comprised of two clinically indistinguishable forms. In HAE type 1, representing 85% of patients, serum levels of C1 esterase inhibitor are less than 35% of normal. In HAE type 2, the levels are normal or elevated, but the protein is non-functional.
    • Sequence similaritiesBelongs to the serpin family.
    • Post-translational
      modifications
      Highly glycosylated (49%) with N- and O-glycosylation.
      Can be proteolytically cleaved by E.coli stcE.
    • Cellular localizationSecreted.
    • Information by UniProt
    • Database links
    • Alternative names
      • C1 esterase inhibitor antibody
      • C1 Inh antibody
      • C1 inhibiting factor antibody
      • C1 inhibitor antibody
      • C1-inhibiting factor antibody
      • C1IN antibody
      • C1Inh antibody
      • C1NH antibody
      • complement component 1 inhibitor antibody
      • esterase inhibitor antibody
      • HAE1 antibody
      • HAE2 antibody
      • IC1_HUMAN antibody
      • Plasma protease C1 inhibitor antibody
      • Serine (or cysteine) proteinase inhibitor clade G member 1 antibody
      • serine/cysteine proteinase inhibitor clade G member 1 antibody
      • Serpin G1 antibody
      • serpin peptidase inhibitor, clade G (C1 inhibitor), member 1 antibody
      • SERPING1 antibody
      see all

    References for Anti-C1 Inactivator antibody [KT28] (ab53365)

    ab53365 has not yet been referenced specifically in any publications.

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